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The article describes the structure, architecture, principles of construction and operating modes of the computer software that simulates operators' workplaces of centrifuge uranium enrichment production. We have implemented the networking of computer simulator modules and equipment database. A computer simulator of the isotope separation plant of Siberian Chemical Plant OJSC has been created on the basis of the architecture developed. The main purpose of the simulator is to train the operating personnel for production process control in standard and emergency situations.