Quantitative determination of new anti-inflammatory drug indomenthyl and its metabolite in rabbit plasma by HPLC-MS/MS / K. A. Leonov, A. V. Bykova, V. V. Bykov [et al.]

Уровень набора: Analytical MethodsАльтернативный автор-лицо: Leonov, K. A., Klim Andreevich;Bykova, A. V., Arina Vladimirovna;Bykov, V. V., Vladimir Valerjevich;Vishenkova, D. A., chemist, engineer of Tomsk Polytechnic University, 1989-, Dariya Aleksandrovna;Lipskikh, O. I., chemist, engineer of Tomsk Polytechnic University, 1984-, Olga Ivanovna;Dorozhko, E. V., chemist, Engineer of Tomsk Polytechnic University, 1979-, Elena Vladimirovna;Pavlovsky, V. I., chemist, Professor of Tomsk Polytechnic University, Doctor of chemical sciences, 1958-, Viktor Ivanovich;Vengerovsky, A. I., Aleksandr Isaakovich;Udut, V. V., Vladimir VasiljevichКоллективный автор (вторичный): Национальный исследовательский Томский политехнический университет, Инженерная школа природных ресурсов, Отделение химической инженерииЯзык: английский.Страна: .Резюме или реферат: Background: Indomenthyl is an innovative anti-inflammatory drug with a high analgesic activity. Indomenthyl releases indomethacin under the influence of neutrophil esterases in the inflammation focus. Methodology/results: This research is aimed at developing a highly sensitive method for the quantitative determination of indomenthyl and its active metabolite indomethacin in rabbit plasma by HPLC-MS/MS. Protein precipitation and extraction with acetonitrile were used for analyte isolation from plasma according to the QuEChERS principle. The target quantitative ion pairs m/z were respectively 496.4 / 358.0 for indomenthyl, 358.0 / 139.5 for indomethacin, and 340.1 / 202.1 for the IS. Conclusion: The calibration curve was linear over the range 0.1-1000 ng mL1 . The technique was applied to the pharmacokinetic study at a dose of 25 mg kg1 to rabbits.Примечания о наличии в документе библиографии/указателя: [References: 24 tit.].Тематика: электронный ресурс | труды учёных ТПУ Ресурсы он-лайн:Щелкните здесь для доступа в онлайн
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[References: 24 tit.]

Background: Indomenthyl is an innovative anti-inflammatory drug with a high analgesic activity. Indomenthyl releases indomethacin under the influence of neutrophil esterases in the inflammation focus. Methodology/results: This research is aimed at developing a highly sensitive method for the quantitative determination of indomenthyl and its active metabolite indomethacin in rabbit plasma by HPLC-MS/MS. Protein precipitation and extraction with acetonitrile were used for analyte isolation from plasma according to the QuEChERS principle. The target quantitative ion pairs m/z were respectively 496.4 / 358.0 for indomenthyl, 358.0 / 139.5 for indomethacin, and 340.1 / 202.1 for the IS. Conclusion: The calibration curve was linear over the range 0.1-1000 ng mL1 . The technique was applied to the pharmacokinetic study at a dose of 25 mg kg1 to rabbits

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