Full 3D basin modeling is finding a practical application in oil and gas exploration. Temis 3D was used for study of oil generation and migration in the part of a prolific hydrocarbon province in Russia. Results of modeling provide new information, which allow to better understand influential factors for the formation and occurrence of oilfields.Transformation ratio of main source rock in the studied area is from 0 to 44 % and firsts accumulations started to form nearly 60 million years ago. There were defined the factors guiding the formation and occurrence of oil fields. Depending on reservoir spreading and source rock maturity the coefficients of oil accumulation in two blocks of studied area differ in eight times. Comparison between proven reserves and reserved computed by Temis shows good accordance.