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The paper deals with the problem of studying spatial anisotropy of hydrocarbon reservoirs using paleomagnetic oriented core samples. Oriented rock samples were studied using complex specialized methods which included specifications of paleomagnetic, petrophysical, lithological, morphological and microstructural sandstones features. As a result, of investigation increase in the parameters of magnetic and acoustic field fluctuations in core samples were determined. Maximum of these parameters are connected with prevalent directions of quartz grains orientation and confirm with the direction of maximum permeability sandstone reservoirs. The anisotropy data for lithological, petrophysical and filtration properties in samples from the studied deposits indicate consistency changes of these characteristics. The joint application of lithological and petrophysical methods allows to receive additional volume of geological information and use it to construct real anisotropic geological and hydrodynamic models of oil fields.