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According to the detailed analysis of geology and hydrogeology in the Yurubcheno-Tokhomo hydrocarbon play (YTHP) the Lower Cambrian Osa horizon has been shown as suitable for the disposal of large volumes of produced and wastewaters. A 3D-model of filtration between the injection (disposal) well and reservoir was used to estimate the contribution of the industrial effluent injection. The highest industrial change in the mineralogical composition and porosity-permeability of reservoir was revealed during treated effluent disposal. Zone of industrial metasomatism was up to 800–840 m by the end of the fifth year of landfill operation.