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This research paper focuses on transformation of university educational processes with introduction of project-based learning to foster entrepreneurship in education. It addresses the educational process in universities in the context of academic entrepreneurship in different country-specific settings. In addition, it explains the factors influencing the development of entrepreneurial education environment exploiting entrepreneurial opportunities in a regional university in Russia. The authors use four case studies of entrepreneurial universities: Massachusetts Institute of Technologies (MIT), National Singapore University (NSU), Moscow Institute of Physics and Technology (MIPT) and Tomsk State University of Control Systems and Radioelectronics (TUSUR).