Neuroprotective effects of p-tyrosol after the global cerebral ischemia in rats / D. N. Atochin [et al.]

Уровень набора: PhytomedicineАльтернативный автор-лицо: Atochin, D. N., neuroscientist, The Head of the Laboratory of Tomsk Polytechnic University, 1960-, Dmitry Nikolaevich;Chernysheva, G. A.;Smolyakova, V. I.;Osipenko, A. N.;Logvinov S. V., S. V.;Zhdankina, A. A.;Sysolyatin, S. V.;Kryukov, Yu. A.;Anfinogenova, Ya. J., Linguist, Lecturer of Tomsk Polytechnic University, Doctor of medical sciences, 1970-, Yana Jonovna;Plotnikova, T. M.;Plotnikov, M. B.Коллективный автор (вторичный): Национальный исследовательский Томский политехнический университет (ТПУ), Управление проректора по научной работе и инновациям (НРиИ), Центр RASA в Томске (Центр RASA), Лаборатория изучения механизмов нейропротекции (Лаб. ИМН)Язык: английский.Резюме или реферат: Background. Salidroside is a biologically active compound derived from Rhodiola rosea L. Studies showed that salidroside after i.v. injection is extensively metabolized to p-tyrosol and only trace amounts of salidroside are found in the brain tissue.Objective. The aim of the study was to investigate the neuroprotective effects of p-tyrosol in the global cerebral ischemia-reperfusion (GCI) model.Study design. A total of 103 Wistar rats were assigned to groups of sham-operated (n = 10), control (n = 42), p-tyrosol-treated (n = 36), and pentoxifylline-treated (n = 15) animals. The rats of control, p-tyrosol-treated, and pentoxifylline-treated groups received intravenously 0.9% NaCl solution, 2% solution of p-tyrosol in doses of 5 mg/kg, 10 mg/kg, and 20 mg/kg, and pentoxifylline in a dose of 100 mg/kg, respectively, daily for 5 days. Rats were examined at days 1, 3, and 5 after GCI. After evaluation of neurological deficit, animals were euthanized for morphological and biochemical characterization..Примечания о наличии в документе библиографии/указателя: [References: p. 791-792 (36 tit.)].Аудитория: .Тематика: электронный ресурс | труды учёных ТПУ Ресурсы он-лайн:Щелкните здесь для доступа в онлайн
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[References: p. 791-792 (36 tit.)]

Background. Salidroside is a biologically active compound derived from Rhodiola rosea L. Studies showed that salidroside after i.v. injection is extensively metabolized to p-tyrosol and only trace amounts of salidroside are found in the brain tissue.Objective. The aim of the study was to investigate the neuroprotective effects of p-tyrosol in the global cerebral ischemia-reperfusion (GCI) model.Study design. A total of 103 Wistar rats were assigned to groups of sham-operated (n = 10), control (n = 42), p-tyrosol-treated (n = 36), and pentoxifylline-treated (n = 15) animals. The rats of control, p-tyrosol-treated, and pentoxifylline-treated groups received intravenously 0.9% NaCl solution, 2% solution of p-tyrosol in doses of 5 mg/kg, 10 mg/kg, and 20 mg/kg, and pentoxifylline in a dose of 100 mg/kg, respectively, daily for 5 days. Rats were examined at days 1, 3, and 5 after GCI. After evaluation of neurological deficit, animals were euthanized for morphological and biochemical characterization.

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