Modulation of Human Neutrophil Responses by the Essential Oils from Ferula akitschkensis and Their Constituents / I. A. Schepetkin, S. V. Kushnarenko, G. Ozek [et al.]

Уровень набора: Journal of Agricultural and Food Chemistry = 1953-Альтернативный автор-лицо: Schepetkin (Shchepyotkin), I. A., doctor-biophysicist, leading researcher of Tomsk Polytechnic University, candidate of medical science, 1962-, Igor Aleksandrovich;Kushnarenko, S. V., Svetlana;Ozek, G., Gulmira;Kirpotina, L. N., Liliya Nikolaevna;Sinharoy, P., Pritam;Utegenova, G. A., Gulzhakhan;Abidkulova, K. T., Karime;Ozek, T., Temel;Baser, K. H. C., Kemal Husnu Can;Kovrizhina, A. R., biotechnology specialist, Research Engineer of Tomsk Polytechnic University, 1995-, Anastasia Ruslanovna;Khlebnikov, A. I., Chemist, Professor of Tomsk Polytechnic University, 1963-, Andrey Ivanovich;Damron, D. S., Derek;Quinn, M. T., MarkКоллективный автор (вторичный): Национальный исследовательский Томский политехнический университет (ТПУ), Институт физики высоких технологий (ИФВТ), Кафедра биотехнологии и органической химии (БИОХ)Язык: английский ; резюме, eng.Страна: .Резюме или реферат: Essential oils were obtained by hydrodistillation of the umbels+seeds and stems of Ferula akitschkensis (FAEOu/s and FAEOstm, respectively) and analyzed by gas chromatography and gas chromatography-mass spectrometry. Fifty-two compounds were identified in FAEOu/s; the primary components were sabinene, α-pinene, β-pinene, terpinen-4-ol, eremophilene, and 2-himachalen-7-ol, whereas the primary components of FAEOstm were myristicin and geranylacetone. FAEOu/s, β-pinene, sabinene, γ-terpinene, geranylacetone, isobornyl acetate, and (E)-2-nonenal stimulated [Ca2+]i mobilization in human neutrophils, with the most potent being geranylacetone (EC50 = 7.6 ± 1.9 μM) and isobornyl acetate 6.4 ± 1.7 (EC50 = 7.6 ± 1.9 μM). In addition, treatment of neutrophils with β-pinene, sabinene, γ-terpinene, geranylacetone, and isobornyl acetate desensitized the cells to N-formyl-Met-Leu-Phe (fMLF)- and interleukin-8 (IL-8)-induced [Ca2+]i flux and inhibited fMLF-induced chemotaxis. The effects of β-pinene, sabinene, γ-terpinene, geranylacetone, and isobornyl acetate on neutrophil [Ca2+]i flux were inhibited by transient receptor potential (TRP) channel blockers..Аудитория: .Тематика: электронный ресурс | труды учёных ТПУ | эфирные масла | человеческий организм | реакции Ресурсы он-лайн:Щелкните здесь для доступа в онлайн
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Essential oils were obtained by hydrodistillation of the umbels+seeds and stems of Ferula akitschkensis (FAEOu/s and FAEOstm, respectively) and analyzed by gas chromatography and gas chromatography-mass spectrometry. Fifty-two compounds were identified in FAEOu/s; the primary components were sabinene, α-pinene, β-pinene, terpinen-4-ol, eremophilene, and 2-himachalen-7-ol, whereas the primary components of FAEOstm were myristicin and geranylacetone. FAEOu/s, β-pinene, sabinene, γ-terpinene, geranylacetone, isobornyl acetate, and (E)-2-nonenal stimulated [Ca2+]i mobilization in human neutrophils, with the most potent being geranylacetone (EC50 = 7.6 ± 1.9 μM) and isobornyl acetate 6.4 ± 1.7 (EC50 = 7.6 ± 1.9 μM). In addition, treatment of neutrophils with β-pinene, sabinene, γ-terpinene, geranylacetone, and isobornyl acetate desensitized the cells to N-formyl-Met-Leu-Phe (fMLF)- and interleukin-8 (IL-8)-induced [Ca2+]i flux and inhibited fMLF-induced chemotaxis. The effects of β-pinene, sabinene, γ-terpinene, geranylacetone, and isobornyl acetate on neutrophil [Ca2+]i flux were inhibited by transient receptor potential (TRP) channel blockers.

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