Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists / L. N. Maslov [et al.]
Уровень набора: Medicinal Research ReviewsЯзык: английский.Страна: .Резюме или реферат: It has now been demonstrated that the µ, δ 1, δ 2, and K 1 opioid receptor (OR) agonists represent the most promising group of opioids for the creation of drugs enhancing cardiac tolerance to the detrimental effects of ischemia/reperfusion (I/R). Opioids are able to prevent necrosis and apoptosis of cardiomyocytes during I/R and improve cardiac contractility in the reperfusion period. The OR agonists exert an infarct-reducing effect with prophylactic administration and prevent reperfusion-induced cardiomyocyte death when ischemic injury of heart has already occurred; that is, opioids can mimic preconditioning and postconditioning phenomena. Furthermore, opioids are also effective in preventing ischemia-induced arrhythmias..Примечания о наличии в документе библиографии/указателя: [References: p. 905-922 (333 tit.)].Аудитория: .Тематика: электронный ресурс | труды учёных ТПУ | opioids | опиоиды | ишемия | реперфузия Ресурсы он-лайн:Щелкните здесь для доступа в онлайнTitle screen
[References: p. 905-922 (333 tit.)]
It has now been demonstrated that the µ, δ 1, δ 2, and K 1 opioid receptor (OR) agonists represent the most promising group of opioids for the creation of drugs enhancing cardiac tolerance to the detrimental effects of ischemia/reperfusion (I/R). Opioids are able to prevent necrosis and apoptosis of cardiomyocytes during I/R and improve cardiac contractility in the reperfusion period. The OR agonists exert an infarct-reducing effect with prophylactic administration and prevent reperfusion-induced cardiomyocyte death when ischemic injury of heart has already occurred; that is, opioids can mimic preconditioning and postconditioning phenomena. Furthermore, opioids are also effective in preventing ischemia-induced arrhythmias.
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