10-Alkenylphenothiazines, 1, Synthesis and cis,trans-isomerization of 10-propenylphenothiazines / V. A. Anfinogenov [et al.]
Уровень набора: Chemistry of Heterocyclic CompoundsЯзык: английский.Резюме или реферат: A study was carried out on the isomerization of 10-allylphenothiazine (I) in DMSO by the action of t-BuOK, KOH and NaOH. The isomerization proceeds stereospecifically at room temperature by the action of t-BuOK at an elevated temperature by the action of KOH and NaOH to give cis-10-propenylphenothiazine (II). The effect of the t-BuOK concentration, temperature and reaction time on the isomeric composition of the 10-propenylphenothiazines formed was studied. Under conditions of kinetic control, I gives II, which isomerizes under the reaction conditions to give an equilibrium mixture of cis- and trans-10-propenyl-phenothiazine with 44-45% trans isomer III. The isomerization temperature has virtually no effect on the II/III isomer ratio..Примечания о наличии в документе библиографии/указателя: [References: 16 tit.].Аудитория: .Тематика: электронный ресурс | труды учёных ТПУ | алкенилфенотиазины | синтез | исследование | изомеризация | температура Ресурсы он-лайн:Щелкните здесь для доступа в онлайнTitle screen
[References: 16 tit.]
A study was carried out on the isomerization of 10-allylphenothiazine (I) in DMSO by the action of t-BuOK, KOH and NaOH. The isomerization proceeds stereospecifically at room temperature by the action of t-BuOK at an elevated temperature by the action of KOH and NaOH to give cis-10-propenylphenothiazine (II). The effect of the t-BuOK concentration, temperature and reaction time on the isomeric composition of the 10-propenylphenothiazines formed was studied. Under conditions of kinetic control, I gives II, which isomerizes under the reaction conditions to give an equilibrium mixture of cis- and trans-10-propenyl-phenothiazine with 44-45% trans isomer III. The isomerization temperature has virtually no effect on the II/III isomer ratio.
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