Experimental Study of a Radiopharmaceutical Agent Based on Modified Fatty Acid Labeled with Technetium-99m / S. I. Sazonova [et al.]

Уровень набора: Bulletin of Experimental Biology and MedicineАльтернативный автор-лицо: Sazonova, S. I., Svetlana Ivanovna;Iljyushenkova, Yu. N., Yuliya Nikolaevna;Lishmanov, Yu. B., specialist in the field of medical technology, lead engineer aof Tomsk Polytechnic University, doctor of medical sciences, 1951-, Yury Borisovich;Tsibulnikov, S. Yu., specialist in the field of medical technology, Senior Lecturer of Tomsk Polytechnic University, Candidate of medical Sciences, 1986-, Sergey Yurjevich;Skuridin, V. S., Physicist, Specialist in the field of nuclear power engineering, Professor of Tomsk Polytechnic University, Doctor of technical sciences, 1946-, Viktor Sergeyevich;Nesterov, E. A., Physicist, Specialist in the field of nuclear power engineering, Researcher of Tomsk Polytechnic University, 1976-, Evgeny Alexandrovich;Varlamova, N. V., biochemist, Researcher of Tomsk Polytechnic University, Candidate of biological sciences, 1975-, Natalya Valeryevna;Tagirova, E. A., physicist, specialist in the field of nuclear physics, engineer of Tomsk Polytechnic University, Candidate of technical sciences, 1990-, Ekaterina Alekseevna;Filimonov, V. D., Russian chemist, Professor of the TPU, 1945-, Viktor Dmitrievich;Belyanin, M. L., organic chemist, Associate Professor of Tomsk Polytechnic University, Candidate of chemical sciences, 1973-, Maksim L'vovich;Stepanova, E. V., chemist, engineer of Tomsk Polytechnic University, 1978-, Elena Vladimirovna;Minin, S. M., specialist in the field of medical technology, laboratory of Tomsk Polytechnic University, candidate of medical science, 1978-, Stanislav MikhaylovichКоллективный автор (вторичный): Национальный исследовательский Томский политехнический университет (ТПУ), Физико-технический институт (ФТИ), Лаборатория радиационного контроля № 31 (Лаборатория РК № 31);Национальный исследовательский Томский политехнический университет (ТПУ), Институт физики высоких технологий (ИФВТ), Кафедра биотехнологии и органической химии (БИОХ)Язык: английский.Резюме или реферат: Using rat model of coronary occlusion, we studied pharmacokinetics and the efficiency of a new radiopharmaceutical agent 99mTc-PDA-DTPA intended for diagnostics of changes in myocardial metabolism and its analogue 123I-PMPDA. 99mTc-PDA-DTPA was eliminated mostly by the kidneys and maximal concentration in the heart was attained within 60 min after intravenous injection; no accumulation in the area of myocardial infarction was observed. The studied substance was inferior to its analogue 123I-PMPDA by the quality of scintigraphic visualization of the heart..Примечания о наличии в документе библиографии/указателя: [References: p. 749 (9 tit.)].Аудитория: .Тематика: электронный ресурс | труды учёных ТПУ | метаболизм | миокард | жирные кислоты Ресурсы он-лайн:Щелкните здесь для доступа в онлайн
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[References: p. 749 (9 tit.)]

Using rat model of coronary occlusion, we studied pharmacokinetics and the efficiency of a new radiopharmaceutical agent 99mTc-PDA-DTPA intended for diagnostics of changes in myocardial metabolism and its analogue 123I-PMPDA. 99mTc-PDA-DTPA was eliminated mostly by the kidneys and maximal concentration in the heart was attained within 60 min after intravenous injection; no accumulation in the area of myocardial infarction was observed. The studied substance was inferior to its analogue 123I-PMPDA by the quality of scintigraphic visualization of the heart.

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