A Novel Glycosyl Donor with a Triisopropylsilyl Nonparticipating Group in Benzyl-Free Stereoselective 1,2-cis-Galactosylation / P. I. Abronina [et al.]
Уровень набора: SynlettЯзык: английский.Страна: .Резюме или реферат: A novel glycosyl donor with a triisopropylsilyl (TIPS) nonparticipating group at O-2 is introduced for use in 1,2-cis-galactosylation. Coupling the 2-O-TIPS-substituted thiogalactoside donor with a series of mono- and disaccharide glycosyl acceptors was found to lead exclusively to a-linked oligosaccharides. The observed exceptionally high a-selectivity was interpreted in terms of conformational changes in the glycosyl cation induced by the bulky 2-O-TIPS group..Примечания о наличии в документе библиографии/указателя: [References: p. 1611-1613 (49 tit.)].Тематика: электронный ресурс | труды учёных ТПУ | glycosylation | stereoselectivity | stereoselective synthesis | conformation | protecting groups | triisopropylsilyl group | 4-(3-chloropropoxy)phenyl glycosides | стереоселективный синтез | конформация | защитные группы | гликозилирование | стереоселективность | фенилгликозиды Ресурсы он-лайн:Щелкните здесь для доступа в онлайн | Щелкните здесь для доступа в онлайнНет реальных экземпляров для этой записи
Title screen
[References: p. 1611-1613 (49 tit.)]
A novel glycosyl donor with a triisopropylsilyl (TIPS) nonparticipating group at O-2 is introduced for use in 1,2-cis-galactosylation. Coupling the 2-O-TIPS-substituted thiogalactoside donor with a series of mono- and disaccharide glycosyl acceptors was found to lead exclusively to a-linked oligosaccharides. The observed exceptionally high a-selectivity was interpreted in terms of conformational changes in the glycosyl cation induced by the bulky 2-O-TIPS group.
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