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Steel castings with large thickness are widely used in different areas of industry and the control of steel castings with large thickness is becoming more and more important in order to detect defects and ensure the reliability. In this paper, we carry out betatron radiography and tomography to control the steel castings with large thickness and check the potential ability of Inspection and Examination System (IES) for a high-energy betatron tomography. The results of betatron radiography and tomography of steel castings with large thickness are presented and compared with precedent work, which shows that the IES is considered a promising high-energy tomography system.