“Solvent/non-solvent” treatment as a method for non-covalent immobilization of gelatin on the surface of poly(l-lactic acid) electrospun scaffolds / S. I. Goreninsky, R. O. Gulyaev, K. S. Stankevich [et al.]

Уровень набора: Colloids and Surfaces B: BiointerfacesАльтернативный автор-лицо: Goreninsky, S. I., chemist, engineer of Tomsk Polytechnic University, 1993-, Semen Igorevich;Gulyaev, R. O., chemical engineer, Research Engineer of Tomsk Polytechnic University, 1995-, Roman Olegovich;Stankevich, K. S., Physicist, Engineer Tomsk Polytechnic University, 1992-, Ksenia Sergeevna;Danilenko, N. V., Physicist, Engineer Tomsk Polytechnic University, 1992-, Nadezhda Viktorovna;Bolbasov, E. N., physicist, Engineer of Tomsk Polytechnic University, 1981-, Evgeny Nikolaevich;Golovkin, A. S., Aleksey Sergeevich;Mishanin, A. I., Aleksandr;Filimonov, V. D., Russian chemist, Professor of the TPU, 1945-, Viktor Dmitrievich;Tverdokhlebov, S. I., physicist, Associate Professor of Tomsk Polytechnic University, Candidate of physical and mathematical science, 1961-, Sergei IvanovichКоллективный автор (вторичный): Национальный исследовательский Томский политехнический университет, Инженерная школа новых производственных технологий, Научно-образовательный центр Н. М. Кижнера;Национальный исследовательский Томский политехнический университет, Инженерная школа ядерных технологий, Научно-образовательный центр Б. П. ВейнбергаЯзык: английский.Резюме или реферат: In the present study, we report a simple and efficient method of gelatin immobilization on the surface of PLA electrospun fibers using pre-treatment with a mixture of toluene and ethanol allowing to form swelled surface layer followed by gelatin adsorption from its solution in PBS. Our results demonstrate that gelatin immobilization leads to a decrease in the water contact angle from 120° to 0°, enhances scaffold strength up to 50%, and doubles the number of adhered cells and their average area. We observed that the maximum amount of gelatin (0.07?±?0.01?mg per cm3 of the scaffold) was immobilized during the first five minutes of exposure to the gelatin solution. Modified scaffolds demonstrated increased strength..Примечания о наличии в документе библиографии/указателя: [References: 19 tit.].Аудитория: .Тематика: электронный ресурс | труды учёных ТПУ | polylactic acid | gelatin | electrospun scaffolds | surface modification | желатин | поверхностный слой | строительные леса Ресурсы он-лайн:Щелкните здесь для доступа в онлайн
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[References: 19 tit.]

In the present study, we report a simple and efficient method of gelatin immobilization on the surface of PLA electrospun fibers using pre-treatment with a mixture of toluene and ethanol allowing to form swelled surface layer followed by gelatin adsorption from its solution in PBS. Our results demonstrate that gelatin immobilization leads to a decrease in the water contact angle from 120° to 0°, enhances scaffold strength up to 50%, and doubles the number of adhered cells and their average area. We observed that the maximum amount of gelatin (0.07?±?0.01?mg per cm3 of the scaffold) was immobilized during the first five minutes of exposure to the gelatin solution. Modified scaffolds demonstrated increased strength.

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