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The purpose of the article is to analyze the possibilities of using predicative analytics in managing the development of single-industry towns (a) to substantiate the trends in the modernization of singleindustry economies, (b) to develop, monitor, and correct projects for diversification, and (c) to form and development of advanced social and economic development (TASED) territories in single-industry towns. To determine the possibility of using predicative (predictive) analytics in the management of single-industry cities, the authors consider the main problems associated with the development and implementation of strategies and programs for the development of mono-profile settlements. In addition, they determine possible directions and possibilities of using predictive analytics (in aggregate, for example, with foresight) in managing the development of single-industry towns: developing and improving state programs to support single-industry towns; forming a strategy for smart specialization; selecting priorities for innovative development; searching for sources of a unique strategy of a single-industry town; foreseeing innovative changes; managing risks of implementing strategies and programs; developing TASED, managing technical risks of enterprises. The authors made a preliminary choice of possible predictors. The results of the research can be helpful in developing the regional economy in terms of tools for long-term planning and forecasting the transformation of economies and societies of singleindustry towns.