Title screen

[References: 26 tit.]

When the spleen is damaged, severe bleeding develops which can lead to death. The aim of this study was to evaluate the effectiveness of cold plasma treatment for performing partial splenectomy as a new organ-preserving technique. Adult male rabbits were used as experimental animals. They were randomly separated into control (5 in total) and experimental (30 in total) groups. Animals from the experimental group had partial splenectomy with subsequent coagulation by cold plasma. Blood loss, complete blood count (CBC), histological tissue samples and splenograms were investigated after 60 min, 3, 5, 14, 90, 180 days following plasma treatment. Contrast-enhanced MR—angiography with 'Gadovist' was performed on the 90th day. The structure of the organ was normalized in the late periods. MR-imaging of the microcirculatory bed on the 90th day after the operation was normal. The effective hemostasis of the spleen in the experiment occurred after treatment with the plasma for 90–100 s. After hemostasis with plasma, spleen parenchyma was damaged, manifested by the general adaptation syndrome but at a later time it regenerated with the formation of a connective tissue scar at a later time. Functions of the spleen were not damaged. These results demonstrate the high efficiency of cold plasma treatment during surgical interventions.