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The problems of the development of the national technological base and specific engineering industries, requiring a radical change in the approach to the organization of scientific and technological development in the Russian industry. The focus of the pool of Sciences (scientific and engineering disciplines) allows to structure the organizational core of scientific (innovative) associations, which allows to raise the question of the layout of the long-term structure of organizational relations and support of leading scientific, as well as educational, design, industrial, etc. organizations. Structuring the "functional core" of enterprises and organizations concentrating key digital technologies in the total mass of economic entities determines the need for the formation of matrix scientific and industrial structures as a kind of associations [on the basis of an information network using elements of artificial intelligence] within the relevant management strategies implemented by machine-building enterprises.