99mTc-labeled monosaccharide kits: development methods and quality control / E. S. Stasyuk (Stasiuk), V. S. Skuridin, A. S. Rogov [et al.]

Уровень набора: Scientific ReportsАльтернативный автор-лицо: Stasyuk (Stasiuk), E. S., Specialist in the field of nuclear power engineering, Researcher of Tomsk Polytechnic University, Candidate of technical sciences, 1978-, Elena Sergeyevna;Skuridin, V. S., Physicist, Specialist in the field of nuclear power engineering, Professor of Tomsk Polytechnic University, Doctor of technical sciences, 1946-, Viktor Sergeyevich;Rogov, A. S., Radiochemist, Engineer of Tomsk Polytechnic University, 1986-, Alexander Sergeyevich;Zelchan, R. V., specialist in the field of medical technology, laboratory Tomsk Polytechnic University, 1984-, Roman Vladimirovich;Sadkin, V. L., Physicist, Associate Scientist of Tomsk Polytechnic University, candidate of technical Sciences, 1986-, Vladimir Leonidovich;Varlamova, N. V., biochemist, Researcher of Tomsk Polytechnic University, Candidate of biological sciences, 1975-, Natalya Valeryevna;Nesterov, E. A., Physicist, Specialist in the field of nuclear power engineering, Researcher of Tomsk Polytechnic University, 1976-, Evgeny AlexandrovichКоллективный автор (вторичный): Национальный исследовательский Томский политехнический университет, Физико-технический институт, Лаборатория № 31 ядерного реактораЯзык: английский.Резюме или реферат: The paper presents the procedure for planning an experiment to create standard sets of reagents for a technetium-99m generator based on glucose derivatives. All stages are presented from researching the required quantities of a substance, a reducing agent, a stabilizer and auxiliary components to developing lyophilized kits and conducting quality control. The radiochemical purity of radiopharmaceuticals prepared on the basis of the developed kits ranged from 90.0 to 99.0%. We also showed the functional suitability of the developed preparations on C57B1/6j mice with an implanted malignant tumor - Lewis lung carcinoma..Примечания о наличии в документе библиографии/указателя: [References: 14 tit.].Тематика: электронный ресурс | труды учёных ТПУ | cancer imaging | drug development | визуализация | рак | разработка | лекарства Ресурсы он-лайн:Щелкните здесь для доступа в онлайн | Щелкните здесь для доступа в онлайн
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[References: 14 tit.]

The paper presents the procedure for planning an experiment to create standard sets of reagents for a technetium-99m generator based on glucose derivatives. All stages are presented from researching the required quantities of a substance, a reducing agent, a stabilizer and auxiliary components to developing lyophilized kits and conducting quality control. The radiochemical purity of radiopharmaceuticals prepared on the basis of the developed kits ranged from 90.0 to 99.0%. We also showed the functional suitability of the developed preparations on C57B1/6j mice with an implanted malignant tumor - Lewis lung carcinoma.

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