Electrospray Preparation of Biocompatible Lactide–Glycolide Copolymer Capsules with Incorporation of Interferon / I. A. Khlusov, E. V. Kibler, V. L. Kudryavtseva [et al.]

Уровень набора: Doklady ChemistryАльтернативный автор-лицо: Khlusov, I. A., biophysicist, Professor of Tomsk Polytechnic University, doctor of medical Sciences, 1963-, Igor Albertovich;Kibler, E. V., specialist in the field of nuclear technologies, Engineer of Tomsk Polytechnic University, 1995-, Elina Vitaljevna;Kudryavtseva, V. L., physicist, Engineer of Tomsk Polytechnic University, 1993-, Valeriya Lvovna;Tverdokhlebov, S. I., physicist, Associate Professor of Tomsk Polytechnic University, Candidate of physical and mathematical science, 1961-, Sergei Ivanovich;Bolbasov, E. N., physicist, Associate Scientist of Tomsk Polytechnic University, Candidate of Sciences, 1981-, Evgeny Nikolaevich;Botvin, V. V., chemist, Senior Researcher of Tomsk Polytechnic University, Candidate of chemical sciences, 1991-, Vladimir Viktorovich;Latypov, A. D., Aleksandr Danisovich;Gatalova, N. D., Natalya Dinislamovna;Litvinova, L. S., Larisa Sergeevna;Buznik, V. M., Vyacheslav Mikhaylovich;Choynzonov, E. L., physicist, chief expert of Tomsk Polytechnic University, 1952-, Evgeny LkhamatsyrenovichКоллективный автор (вторичный): Национальный исследовательский Томский политехнический университет, Инженерная школа природных ресурсов, Отделение геологии;Национальный исследовательский Томский политехнический университет, Инженерная школа ядерных технологий, Отделение ядерно-топливного цикла;Национальный исследовательский Томский политехнический университет, Инженерная школа ядерных технологий, Научно-образовательный центр Б. П. ВейнбергаЯзык: английский.Страна: .Резюме или реферат: The electrospray method was used for the first time to prepare polymeric capsules from bioresorbable dl-lactide and glycolide copolymer loaded with biological molecules from the cell secretome and, in particular, human interferon-?-2b (IFN?-2b). The obtained nearly spherical submicron capsules were studied by scanning electron and confocal laser microscopy. The capsules retain the structural integrity and the cytotoxic activity of IFN?-2b towards tumor cells. The electrospray method is distinguished by high adaptability and environmental safety and is suitable for manufacture of a broad range of materials with different composition and morphology promising for the targeted delivery of drugs and biological molecules..Примечания о наличии в документе библиографии/указателя: [References: 14 tit.].Аудитория: .Тематика: электронный ресурс | труды учёных ТПУ Ресурсы он-лайн:Щелкните здесь для доступа в онлайн
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[References: 14 tit.]

The electrospray method was used for the first time to prepare polymeric capsules from bioresorbable dl-lactide and glycolide copolymer loaded with biological molecules from the cell secretome and, in particular, human interferon-?-2b (IFN?-2b). The obtained nearly spherical submicron capsules were studied by scanning electron and confocal laser microscopy. The capsules retain the structural integrity and the cytotoxic activity of IFN?-2b towards tumor cells. The electrospray method is distinguished by high adaptability and environmental safety and is suitable for manufacture of a broad range of materials with different composition and morphology promising for the targeted delivery of drugs and biological molecules.

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