Solution blow spinning of PLLA/hydroxyapatite composite scaffolds for bone tissue engineering / A. V. Popkov, D. E. Kulbakin, V. V. Popkov [et al.]

Уровень набора: Biomedical MaterialsАльтернативный автор-лицо: Popkov, A. V., Aleksandr Viktorovich;Kulbakin, D. E., Denis Evgenjevich;Popkov, V. V., Vyacheslav Vladimirovich;Gorbach, E. N., Elena Nikolaevna;Kononovich, N. A., Nataljya Andreevna;Danilenko, N. V., chemical engineer, Research Engineer, Tomsk Polytechnic University, 1992-, Nadezhda Viktorovna;Stankevich, K. S., Physicist, Engineer Tomsk Polytechnic University, 1992-, Ksenia Sergeevna;Choynzonov, E. L., physicist, chief expert of Tomsk Polytechnic University, 1952-, Evgeny Lkhamatsyrenovich;Zheravin, A. A., Aleksandr Aleksandrovich;Khlusov, I. A., biophysicist, Professor of Tomsk Polytechnic University, doctor of medical Sciences, 1963-, Igor Albertovich;Bondar, L. N., Ludmila Nikolaevna;Perelmuter, V. M., Vladimir Mikhaylovich;Bolbasov, E. N., physicist, Associate Scientist of Tomsk Polytechnic University, Candidate of Sciences, 1981-, Evgeny Nikolaevich;Tverdokhlebov, S. I., physicist, Associate Professor of Tomsk Polytechnic University, Candidate of physical and mathematical science, 1961-, Sergei IvanovichКоллективный автор (вторичный): Национальный исследовательский Томский политехнический университет, Инженерная школа ядерных технологий, Лаборатория плазменных гибридных систем;Национальный исследовательский Томский политехнический университет, Инженерная школа ядерных технологий, Научно-образовательный центр Б. П. ВейнбергаЯзык: английский.Страна: .Резюме или реферат: Composite poly-L-lactide acid-based scaffolds with hydroxyapatite (HAp) content up to 75 wt.% were fabricated via solution blow spinning. The influence of HAp concentration on structure, wettability, mechanical properties and chemical and phase composition of the produced materials was examined. It was found that with an increase of HAp content the average fiber diameter was increased, the uniaxial strength and relative elongation were reduced, while the phase composition and surface wettability did not change. The performance of the scaffolds during implantation in the parietal bone of a rat skull for a period from 15 to 90 days was studied. The materials have shown high ability to integrate with both soft and hard tissues. It was found that scaffolds with 25 wt.% HAp content significantly enhance osteogenesis during scarification (damage) of the periosteum. Overall, the fabricated scaffolds proved to be highly efficient for replacing bone defects in long tubular bones..Примечания о наличии в документе библиографии/указателя: [References: 58 tit.].Тематика: электронный ресурс | труды учёных ТПУ Ресурсы он-лайн:Щелкните здесь для доступа в онлайн
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[References: 58 tit.]

Composite poly-L-lactide acid-based scaffolds with hydroxyapatite (HAp) content up to 75 wt.% were fabricated via solution blow spinning. The influence of HAp concentration on structure, wettability, mechanical properties and chemical and phase composition of the produced materials was examined. It was found that with an increase of HAp content the average fiber diameter was increased, the uniaxial strength and relative elongation were reduced, while the phase composition and surface wettability did not change. The performance of the scaffolds during implantation in the parietal bone of a rat skull for a period from 15 to 90 days was studied. The materials have shown high ability to integrate with both soft and hard tissues. It was found that scaffolds with 25 wt.% HAp content significantly enhance osteogenesis during scarification (damage) of the periosteum. Overall, the fabricated scaffolds proved to be highly efficient for replacing bone defects in long tubular bones.

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