Title screen

[References: 15 tit.]

The effects of dynamic and static load on the intracellular concentrations of sodium (Na+i)(Nai+) and potassium (K+i) in m. soleus and m. biceps, respectively, were studied in mice. Both dynamic (swimming for 60 min) and static (hanging on the grid for 40 min) load led to a 2-fold increase in Na+iNai+ level, a decrease in K+i concentration by 25-35%, and 3-4-fold increase in the Na+i/K+iNai+/Ki+ ratio. These effects of dynamic and static loads on the studied parameters remained unchanged in mice subjected to regular physical exercise (swimming or hanging on the grid for 1 h a day over 4 weeks). Our results suggest that dissipation of sodium and potassium transmembrane gradients during physical exercise can be considered as a factor of regulation of functional activity of skeletal muscles, which includes changes in transcription and translation of myokines observed previously.