Ligand-free Ullmann-type arylation of oxazolidinones by diaryliodonium salts / E. V. Podrezova, A. A. Okhina, A. D. Rogachev [et al.]

Уровень набора: Organic and Biomolecular ChemistryАльтернативный автор-лицо: Podrezova, E. V., Chemist, Engineer of Tomsk Polytechnic University, 1992-, Ekaterina Vladimirovna;Okhina, A. A., Alina Aleksandrovna;Rogachev, A. D., Artem Dmitrievich;Baykov, S. V., chemist, Researcher at Tomsk Polytechnic University, Candidate of Chemical Sciences, 1987-, Sergey Valentinovich;Kirschning, A., Andreas;Yusubov, M. S., chemist, Professor of Tomsk Polytechnic University, Doctor of chemical sciences, 1961-, Mekhman Suleiman-Ogly (Suleimanovich);Soldatova, N. S., organic chemist, engineer of Tomsk Polytechnic University, 1992-, Nataliya Sergeevna;Postnikov, P. S., organic chemist, Associate Professor of Tomsk Polytechnic University, Candidate of chemical sciences, 1984-, Pavel SergeevichКоллективный автор (вторичный): Национальный исследовательский Томский политехнический университет, Исследовательская школа химических и биомедицинских технологий, (2017- )Язык: английский.Страна: .Резюме или реферат: The arylation of azaheterocycles can be considered as one of the most important processes for the preparation of various biologically active compounds. In the present work, we describe a method for the copper-catalyzed N-arylation of hindered oxazolidinones using diaryliodonium salts. The method succeeds in good to excellent yields for the arylation of 4-alkyloxazolidinones, including sterically hindered isopropyl- and tert-butyl-substituted. The efficiency of the method was demonstrated for a wide range of diaryliodonium salts – symmetric and unsymmetric as well as ortho-substituted derivatives. The developed approach will provide an important contribution in the development and preparation of novel drugs and bioactive molecules containing oxazolidinone moieties..Аудитория: .Тематика: электронный ресурс | труды учёных ТПУ Ресурсы он-лайн:Щелкните здесь для доступа в онлайн
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The arylation of azaheterocycles can be considered as one of the most important processes for the preparation of various biologically active compounds. In the present work, we describe a method for the copper-catalyzed N-arylation of hindered oxazolidinones using diaryliodonium salts. The method succeeds in good to excellent yields for the arylation of 4-alkyloxazolidinones, including sterically hindered isopropyl- and tert-butyl-substituted. The efficiency of the method was demonstrated for a wide range of diaryliodonium salts – symmetric and unsymmetric as well as ortho-substituted derivatives. The developed approach will provide an important contribution in the development and preparation of novel drugs and bioactive molecules containing oxazolidinone moieties.

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