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The article focuses on study in the properties of low-permeable reservoirs. The object of the research is the Bazhenov formation rocks taken from a well drilled in an oilfield of the West Siberian basin. A series of experiments were carried out to determine porosity of rocks by different methods: the helium saturation, nuclear magnetic resonance (NMR), microcomputed tomography (mCT). A comparative analysis was conducted to assess the efficiency of different methods. The obtained results have shown that common methods of petrophysical surveys are insufficient for carbonate-argillaceous Low-permeable rocks, containing a great amount of hand extractable organic matter. The additional data received by the mCT method gave an opportunity to increase sufficiently the reliability of the research results. We have concluded that the most efficient method for the study of low-permeable rocks is a combined use of the NMR and the mCT.