Title screen

Objectives - The aim of this pilot study was to elucidate the effects of exogenous nitric oxide <https://www.sciencedirect.com/topics/medicine-and-dentistry/nitric-oxide>(NO) supply to the extracorporeal circulation <https://www.sciencedirect.com/topics/medicine-and-dentistry/extracorporeal-circulation> circuit for cardioprotection <https://www.sciencedirect.com/topics/medicine-and-dentistry/heart-protection> against -ischemiareperfusion injury <https://www.sciencedirect.com/topics/medicine-and-dentistry/reperfusion-injury> during coronary artery bypass grafting <https://www.sciencedirect.com/topics/medicine-and-dentistry/coronary-artery-bypass-graft> (CABG) with cardiopulmonary bypass <https://www.sciencedirect.com/topics/medicine-and-dentistry/cardiopulmonary-bypass> (CPB). Methods -A total of 60 patients with coronary artery disease <https://www.sciencedirect.com/topics/medicine-and-dentistry/coronary-artery-disease> scheduled for CABG with CPB were enrolled in a prospective randomized study. Patients were allocated randomly to receive treatment according to standard or modified CPB protocol where 40-ppm NO was added to the CPB circuit during cardiac surgery <https://www.sciencedirect.com/topics/medicine-and-dentistry/heart-surgery>. The primary endpoint was the measurement of cardiac troponin I <https://www.sciencedirect.com/topics/medicine-and-dentistry/troponin-i> (cTnI). The secondary end points consisted in the measurements of creatine kinase-muscle/brain fraction (CK-MB) and vasoactive inotropic <https://www.sciencedirect.com/topics/medicine-and-dentistry/inotropism> score (VIS).

Results - NO delivered into the CPB circuit had a cardioprotective effect. The level of cTnI was significantly lower in NO-treated group compared with the control group 6 hours after surgery: 1.79 ± 0.39 ng/mL versus 2.41 ± 0.55 ng/mL, respectively (P = .001). The CK-MB value was significantly lower in NO-treated group compared with the control group 24 hours after surgery: 47.69 ± 8.08 U/L versus 62.25 ± 9.78 U/L, respectively (P = .001); and the VIS was significantly lower in the NO-treated group 6 hours after the intervention. Conclusions - NO supply to the CPB circuit during CABG exerted a cardioprotective effect and was associated with lower levels of VIS and cardiospecific blood markers cTnI and CK-MB.