| 000 | 02817nlm1a2200409 4500 | ||
|---|---|---|---|
| 001 | 638983 | ||
| 005 | 20231030040304.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\3380 | ||
| 090 | _a638983 | ||
| 100 | _a20150218a2014 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 102 | _aUS | ||
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aExercise and NO production: relevance and implications inthe cardiopulmonary system _fA. V. Nosarev [et al.] |
|
| 203 |
_aText _celectronic |
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| 300 | _aTitle screen | ||
| 320 | _a[References: 131 tit.] | ||
| 330 | _aThis article reviews the existing knowledge about the effects of physical exercise on nitric oxide (NO) production in the cardiopulmonary system. The authors review the sources of NO in the cardiopulmonary system; involvement of three forms of NO synthases (eNOS, nNOS, and iNOS) in exercise physiology; exercise-induced modulation of NO and/or NOS in physiological and pathophysiological conditions in human subjects and animal models in the absence and presence of pharmacological modulators; and significance of exercise-induced NO production in health and disease. The authors suggest that physical activity significantly improves functioning of the cardiovascular system through an increase in NO bioavailability, potentiation of antioxidant defense, and decrease in the expression of reactive oxygen species-forming enzymes. Regular physical exercises are considered a useful approach to treat cardiovascular diseases. Future studies should focus on detailed identification of (i) the exercise-mediated mechanisms of NO exchange; (ii) optimal exercise approaches to improve cardiovascular function in health and disease; and (iii) physical effort thresholds. | ||
| 461 | _tFrontiers in Cell and Developmental Biology | ||
| 463 |
_tVol. 2 _v[P. 73] _d2014 |
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| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _anitric oxide | |
| 610 | 1 | _anitric oxide synthase | |
| 610 | 1 | _aexercise | |
| 610 | 1 | _acardiopulmonary system | |
| 610 | 1 | _ablood vessels | |
| 701 | 1 |
_aNosarev _bA. V. _cmedic _cProfessor of Tomsk Polytechnic University, Doctor of medical sciences _f1977- _gAleksey Valerievich _2stltpush _3(RuTPU)RU\TPU\pers\33596 |
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| 701 | 1 |
_aSmagliy _bL. V. |
|
| 701 | 1 |
_aAnfinogenova _bYa. J. _cmedic _cLecturer of Tomsk Polytechnic University, Doctor of medical sciences _f1970- _gYana Jonovna _2stltpush _3(RuTPU)RU\TPU\pers\33592 |
|
| 701 | 1 |
_aPopov _bS. V. |
|
| 701 | 1 |
_aKapilevich _bL. V. _cspecialist in the field of physical culture and sports _cProfessor of Tomsk Polytechnic University, Doctor of medical sciences _f1963- _gLeonid Vladimirovich _2stltpush _3(RuTPU)RU\TPU\pers\33522 |
|
| 801 | 2 |
_aRU _b63413507 _c20150317 _gRCR |
|
| 856 | 4 | _uhttp://dx.doi.org/10.3389%2Ffcell.2014.00073 | |
| 942 | _cCF | ||