| 000 | 03506nla2a2200397 4500 | ||
|---|---|---|---|
| 001 | 640075 | ||
| 005 | 20231030040339.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\4605 | ||
| 035 | _aRU\TPU\network\474 | ||
| 090 | _a640075 | ||
| 100 | _a20150409a2015 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 105 | _ay z 100zy | ||
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aProduction of Meta-Iodobenzilguanidine, 123I Preparation for Medical Diagnostics _fV. S. Slamkulov [et al.] |
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| 203 |
_aText _celectronic |
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| 300 | _aTitle screen | ||
| 330 | _aThis paper demonstrates a method for production of the radiopharmaceutical meta-iodobenzilguanidin (MIBG) labeled with radionuclide iodine-123 (123I). An experimental installation has been developed and the conditions of solid-phase synthesis of the preparation have been described. The influence of the content of ammonium sulfate in the reaction mixture and the temperature and duration of dry synthesis on the process of labeling has been researched. It has been established experimentally that when the ratio of MIBG and ammonium sulfate is 1:4, it is efficient to carry out synthesis at the temperature of 150°C to rapidly obtain a preparation with radiochemical purity of over 97%. Biomedical tests of the synthesized preparation have been carried out in experimental animals. Its functional suitability for scintigraphic studies has been shown. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 | 1 |
_0(RuTPU)RU\TPU\network\4598 _tAdvanced Materials Research : Radiation and nuclear techniques in material science _oScientific Journal |
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| 463 | 1 |
_0(RuTPU)RU\TPU\network\4600 _tVol. 1084 : Physical-Technical Problems of Nuclear Science, Energy Generation, and Power Industry (PTPAI -2014) _oThe VIth International Conference, June 5-7, 2014, Tomsk, Russia _o[proceedings] _fNational Research Tomsk Polytechnic University (TPU) _v[P. 451-455] _d2015 |
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| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aрадиофармацевтика | |
| 610 | 1 | _aйод | |
| 701 | 1 |
_aSlamkulov _bV. S. |
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| 701 | 1 |
_aSkuridin _bV. S. _cPhysicist, Specialist in the field of nuclear power engineering _cProfessor of Tomsk Polytechnic University, Doctor of technical sciences _f1946- _gViktor Sergeyevich _2stltpush _3(RuTPU)RU\TPU\pers\32655 |
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| 701 | 1 |
_aSemenov _bA. S. |
|
| 701 | 1 |
_aGarapatski _bA. A. _cphysicist, specialist in the field of nuclear technology _cLeading engineer of Tomsk Polytechnic University _f1957- _gAlexander Alexandrovich _2stltpush _3(RuTPU)RU\TPU\pers\33123 |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bФизико-технический институт (ФТИ) _bЛаборатория № 31 ядерного реактора (Лаборатория № 31 ЯР) _h6471 _2stltpush _3(RuTPU)RU\TPU\col\20054 |
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bФизико-технический институт (ФТИ) _bЛаборатория получения радиоактивных веществ _h6478 _2stltpush _3(RuTPU)RU\TPU\col\19672 |
| 801 | 2 |
_aRU _b63413507 _c20161228 _gRCR |
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| 856 | 4 | _uhttp://dx.doi.org/10.4028/www.scientific.net/AMR.1084.451 | |
| 942 | _cCF | ||