| 000 | 03545nlm1a2200397 4500 | ||
|---|---|---|---|
| 001 | 640158 | ||
| 005 | 20231030040343.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\4688 | ||
| 090 | _a640158 | ||
| 100 | _a20150410a2015 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aCytochrome P450 1A2 co-determines neuroleptic load and may diminish tardive dyskinesia by increased inducibility _fS. A. Ivanova [et al.] |
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| 203 |
_aText _celectronic |
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| 300 | _aTitle screen | ||
| 330 | _aObjectives. The aim of this study was to investigate a possible association between tardive dyskinesia (TD) and CYP1A2 (*1F, -163C>А, rs762551) polymorphism in Russian psychiatric inpatients. Methods. TD was assessed cross-sectionally using the Abnormal Involuntary Movement Scale (AIMS). Orofacial and limb-truncal dyskinesia were assessed with AIMS 1–4 and 5–7, respectively. Standard protocols were applied for genotyping. Analysis of covariance (ANCOVA) was used to compare the mean AIMS scores for each of the genotypic classes. Results. A total of 319 Caucasian patients from West Siberia with schizophrenia and 117 healthy volunteers were investigated. No significant differences between the patients and the controls in genotype frequencies were found. Analysis of covariance (ANCOVA) with age, sex, duration of disease, chlorpromazine equivalent (CPZEQ) incorporated as covariates showed that limb-truncal, but not orofacial TD, is associated with CYP1A2 (?163C>, rs762551) polymorphism (F = 3.27, P = 0.039). Patients with the C/C genotype had a higher mean AIMS 5–7 score than those with the A/C or the A/A genotype. Conclusions. Our results support the hypothesis that not only with clozapine, but also with other classical and atypical antipsychotics, smoking may decrease plasma levels; this is most extensively expressed in carriers of the CYP1A2*1F (-163C> A) polymorphism. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 | _tThe World Journal of Biological Psychiatry | ||
| 463 |
_tVol. 16, iss. 3 _v[P. 200-205] _d2015 |
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| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 701 | 1 |
_aIvanova _bS. A. _cspecialist in the field of ecology and life safety _cProfessor of Tomsk Polytechnic University, doctor of medical sciences _f1964- _gSvetlana Aleksandrovna _2stltpush _3(RuTPU)RU\TPU\pers\33859 |
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| 701 | 1 |
_aToshchakova _bV. A. _gValentina Aleksandrovna |
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| 701 | 1 |
_aFilipenko _bM. L. _gMaksim Leonidovich |
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| 701 | 1 |
_aFedorenko _bO. Yu. _cspecialist in the field of ecology and life safety _cProfessor of Tomsk Polytechnic University, doctor of medical sciences _f1973- _gOlga Yurievna _2stltpush _3(RuTPU)RU\TPU\pers\33861 |
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| 701 | 1 |
_aBoyarko _bE. G. _gEvgeniya Grigorjevna |
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| 701 | 1 |
_aSemke _bA. V. _gArkady Valentinovich |
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| 701 | 1 |
_aBokhan _bN. A. _gNikolay Aleksandrovich |
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| 701 | 1 |
_aAftanas _bL. V. _gLyubomir Ivanovich |
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| 701 | 1 |
_aLunen _bA. D. _gAnton DzhM |
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| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bИнститут неразрушающего контроля (ИНК) _bКафедра экологии и безопасности жизнедеятельности (ЭБЖ) _h4850 _2stltpush _3(RuTPU)RU\TPU\col\18720 |
| 801 | 2 |
_aRU _b63413507 _c20160606 _gRCR |
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| 856 | 4 | _uhttp://dx.doi.org/10.3109/15622975.2014.995222 | |
| 942 | _cCF | ||