| 000 | 03738nlm1a2200337 4500 | ||
|---|---|---|---|
| 001 | 647981 | ||
| 005 | 20231030040821.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\13138 | ||
| 090 | _a647981 | ||
| 100 | _a20160429a2015 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aInfluence of Antihypertensive Therapy on Cerebral Perfusion in Patients with Metabolic Syndrome: Relationship with Cognitive Function and 24-h Arterial Blood Pressure Monitoring _fN. Yu. Efimova [et al.] |
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| 203 |
_aText _celectronic |
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| 300 | _aTitle screen | ||
| 320 | _a[References: 36 tit.] | ||
| 330 | _aAimsTo investigate the regional cerebral blood flow, cognitive function, and parameters of 24-h arterial blood pressure monitoring in patients with metabolic syndrome before and after combination antihypertensive therapy.MethodsThe study involved 54 patients with metabolic syndrome (MetS) investigated by brain single-photon emission computed tomography, 24-h blood pressure monitoring (ABPM), and comprehensive neuropsychological testing before and after 24 weeks of combination antihypertensive therapy.ResultsPatients with metabolic syndrome had significantly poorer regional cerebral blood flow compared with control group: by 7% (P = 0.003) in right anterior parietal cortex, by 6% (P = 0.028) in left anterior parietal cortex, by 8% (P = 0.007) in right superior frontal lobe, and by 10% (P = 0.00002) and 7% (P = 0.006) in right and left temporal brain regions, correspondingly. The results of neuropsychological testing showed 11% decrease in mentation (P = 0.002), and 19% (P = 0.011) and 20% (P = 0.009) decrease in immediate verbal and visual memory in patients with MetS as compared with control group. Relationships between the indices of ABPM, cerebral perfusion, and cognitive function were found. Data showed an improvement of regional cerebral blood flow, ABPM parameters, and indicators of cognitive functions after 6 months of antihypertensive therapy in patients with MetS.ConclusionThe study showed the presence of diffuse disturbances in cerebral perfusion is associated with cognitive disorders in patients with metabolic syndrome. Combination antihypertensive treatment exerts beneficial effects on the 24-h blood pressure profile, increases cerebral blood flow, and improves cognitive function in patients with MetS. | ||
| 461 | _tCardiovascular Therapeutics | ||
| 463 |
_tVol. 33, iss. 4 _v[P. 209-215] _d2015 |
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| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 701 | 1 |
_aEfimova _bN. Yu. _cspecialist in the field of medical technology _claboratory assistant of Tomsk Polytechnic University, Doctor of medical science _f1972- _gNataliya Yurievna _2stltpush _3(RuTPU)RU\TPU\pers\34257 |
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| 701 | 1 |
_aChernov _bV. I. _cspecialist in the field of medical technology _clead engineer of Tomsk Polytechnic University, doctor of medical sciences _f1962- _gVladimir Ivanovich _2stltpush _3(RuTPU)RU\TPU\pers\34191 |
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| 701 | 1 |
_aEfimova _bI. Yu. _gIrina Yurjevna |
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| 701 | 1 |
_aLishmanov _bYu. B. _cspecialist in the field of medical technology _clead engineer aof Tomsk Polytechnic University, doctor of medical sciences _f1951- _gYury Borisovich _2stltpush _3(RuTPU)RU\TPU\pers\34200 |
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| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bФизико-технический институт (ФТИ) _bЛаборатория № 31 ядерного реактора (Лаборатория № 31 ЯР) _h6471 _2stltpush _3(RuTPU)RU\TPU\col\20054 |
| 801 | 2 |
_aRU _b63413507 _c20160429 _gRCR |
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| 856 | 4 | _uhttp://dx.doi.org/10.1111/1755-5922.12136 | |
| 942 | _cCF | ||