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100			_a20160523a2016 k y0engy50 ba
101	0		_aeng
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181		0	_ai
182		0	_ab
200	1		_aRecurrence of squamous cell lung carcinoma is associated with the co-presence of reactive lesions in tumor-adjacent bronchial epithelium _fO. V. Pankova [et al.]
203			_aText _celectronic
300			_aTitle screen
320			_a[References: 35 tit.]
330			_aRecurrences occur in 30 % of lung cancer patients after radical therapy; however, known prognostic factors are not always effective. In this study, we investigated whether the frequency of squamous non-small cell lung cancer (NSCLC) recurrence depends on the presence of reactive lesions in tumor-adjacent bronchial epithelium. Specimens of adjacent lung tissue from 104 patients with squamous NSCLC were used for the determination of basal cell hyperplasia (BCH) and squamous metaplasia (SM) and for the analysis of the expression of Ki-67, p53, Bcl-2, and CD138. We found that recurrence was observed in 36.7 % of patients with BCH combined with SM (BCH + SM+) in the same bronchus, compared with 1.8 % in patients with isolated BCH (BCH + SM?; odds ratio (OR) 31.26, 95 % confidence interval (CI) 3.77–258.60; p=?0.00002). The percentage of Ki-67-positive cells was significantly higher in BCH + SM+ than in BCH + SM? (34.9 vs. 18.3 %; effect size 2.86, 95 % CI 2.23–3.47; p?=?0.003). P53 expression was also more significant in BCH + SM+ than in BCH + SM? (14.4 vs. 9.6 %; effect size 1.22, 95 % CI 0.69–1.76; p=0.0008). In contrast, CD138 expression was lower in BCH + SM+ than in BCH + SM (21.8 vs. 38.5 %; effect size ?6.26, 95 % CI ?7.31 to ?5.22; p=?0.003). Based on our results, we concluded that the co-presence of reactive bronchial lesions is associated with the development of recurrent squamous NSCLC and may be a negative prognostic indicator. In addition, significant differences in Ki-67, p53, and CD138 expression exist between isolated BCH and BCH combined with SM that probably reflect part of biological differences, which could relate to the mechanism of lung cancer recurrence.
333			_aРежим доступа: по договору с организацией-держателем ресурса
461			_tTumor Biology _oScientific Journal _d1965-
463			_tVol. 37, iss. 3 _v[P. 3599-3609] _d2016
610	1		_aэлектронный ресурс
610	1		_aтруды учёных ТПУ
610	1		_aрекуррентность
610	1		_aрак легких
701		1	_aPankova _bO. V. _gOlga Vladimirovna
701		1	_aDenisov _bE. V. _gEvgeny Vladimirovich
701		1	_aPonomareva _bA. A. _cbiologist _cexpert of Tomsk Polytechnic University, candidate of biological sciences _f1985- _gAnastasiya Alekseevna _2stltpush _3(RuTPU)RU\TPU\pers\36792
701		1	_aGerashchenko _bT. S. _gTatiana Sergeevna
701		1	_aTuzikov _bS. A. _gSergey Alexandrovich
701		1	_aPerelmuter _bV. M. _gVladimir Mikhaylovich
712	0	2	_aНациональный исследовательский Томский политехнический университет (ТПУ) _bФизико-технический институт (ФТИ) _bКафедра прикладной физики (№ 12) (ПФ) _h46 _2stltpush _3(RuTPU)RU\TPU\col\18729
801		2	_aRU _b63413507 _c20160524 _gRCR
856	4	0	_uhttp://dx.doi.org/10.1007/s13277-015-4196-2
942			_cCF