| 000 | 02891nlm1a2200469 4500 | ||
|---|---|---|---|
| 001 | 650316 | ||
| 005 | 20231030040941.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\15534 | ||
| 035 | _aRU\TPU\network\15509 | ||
| 090 | _a650316 | ||
| 100 | _a20161003a2015 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 102 | _aUS | ||
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aSynthesis and Biological Evaluation of Furanoallocolchicinoids _fY. V. Voitovich [et al.] |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 320 | _a[References: p. 702-704 (47 tit.)] | ||
| 330 | _aA series of conformationally flexible furan-derived allocolchicinoids was prepared from commercially available colchicine in good to excellent yields using a three-step reaction sequence. Cytotoxicity studies indicated the potent activity of two compounds against human epithelial and lymphoid cell lines (AsPC-1, HEK293, and Jurkat) as well as against Wnt-1 related murine epithelial cell line W1308. The results of in vitro experiments demonstrated that the major effect of these compounds was the induction of cell cycle arrest in the G2/M phase as a direct consequence of effective tubulin binding. In vivo testing of the most potent furanoallocolchicinoid 10c using C57BL/6 mice inoculated with Wnt-1 tumor cells indicated significant inhibition of the tumor growth. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 |
_tJournal of Medicinal Chemistry _oScientific Journal |
||
| 463 |
_tVol. 58, iss. 2 _v[P. 692–704] _d2015 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 701 | 1 |
_aVoitovich _bY. V. _gYuliya |
|
| 701 | 1 |
_aShegravina _bE. S. _gEkaterina |
|
| 701 | 1 |
_aSitnikov _bN. S. _gNikolay |
|
| 701 | 1 |
_aFaerman _bV. I. _gVladimir |
|
| 701 | 1 |
_aFokin _bV. V. _cchemist _cLeading researcher of Tomsk Polytechnic University _f1971- _gValery Valerjevich _2stltpush _3(RuTPU)RU\TPU\pers\37351 |
|
| 701 | 1 |
_aSchmalz _bH.-G. _gHans-Gunther |
|
| 701 | 1 |
_aCombes _bS. _gSebastien |
|
| 701 | 1 |
_aAllegro _bD. _gDiane |
|
| 701 | 1 |
_aBarbier _bP. _gPascal |
|
| 701 | 1 |
_aBeletskaya _bI. P. _gIrina |
|
| 701 | 1 |
_aSvirshchevskaya _bE. V. _gElena |
|
| 701 | 1 |
_aFedorov _bA. Yu. _gAlexey |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bУправление проректора по научной работе и инновациям (НРиИ) _bЦентр RASA в Томске (Центр RASA) _bЛаборатория изучения механизмов сигнальной трансдукции (Лаб. ИМСТ) _h7610 _2stltpush _3(RuTPU)RU\TPU\col\21811 |
| 801 | 2 |
_aRU _b63413507 _c20161003 _gRCR |
|
| 856 | 4 | _uhttp://dx.doi.org/10.1021/jm501678w | |
| 942 | _cCF | ||