| 000 | 03482nlm1a2200385 4500 | ||
|---|---|---|---|
| 001 | 650326 | ||
| 005 | 20231030040941.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\15544 | ||
| 035 | _aRU\TPU\network\14622 | ||
| 090 | _a650326 | ||
| 100 | _a20161003a2016 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aPhotodynamic therapy platform based on localized delivery of photosensitizer by vaterite submicron particles _fYu. I. Svenskaya [et al.] |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 320 | _a[References: p. 178-179 (62 tit.)] | ||
| 330 | _aThe elaboration of biocompatible and biodegradable carriers for photosensitizer targeted delivery is one of the most promising approaches in a modern photodynamic therapy (PDT). This approach is aimed at reducing sides effects connected with incidental toxicity in healthy tissue whilst also enhancing drug accumulation in the tumour area. In the present work, Photosens-loaded calcium carbonate (CaCO3) submicron particles in vaterite modification are proposed as a novel platform for anticancer PDT. Fast penetration of the carriers (0.9 ± 0.2 μm in diameter) containing 0.12% (w/w) of the photosensitizer into NIH3T3/EGFP cells is demonstrated. The captured particles provide the dye localization inside the cell increasing its local concentration, compared with “free” Photosens solution which is uniformly distributed throughout the cell. The effect of photosensitizer encapsulation into vaterite submicron particles on cell viability under laser irradiation (670 nm, 19 mW/cm2, 10 min) is discussed in the work. As determined by a viability assay, the encapsulation renders Photosens more phototoxic. By this means, CaCO3 carriers allow improvement of the photosensitizer effectiveness supposing, therefore, the reduction of therapeutic dose. Summation of these effects with the simplicity, upscalability and cheapness of fabrication, biocompatibility and high payload ability of the vaterite particles hold out the prospect of a novel PDT platform. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 |
_tColloids and Surfaces B: Biointerfaces _oScientific Journal |
||
| 463 |
_tVol. 146 _v[P. 171–179] _d2016 |
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| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 701 | 1 |
_aSvenskaya _bYu. I. |
|
| 701 | 1 |
_aPavlov _bA. M. |
|
| 701 | 1 |
_aGorin _bD. A. _cchemist _cLeading researcher of Tomsk Polytechnic University _f1975- _gDmitry Aleksandrovich _2stltpush _3(RuTPU)RU\TPU\pers\37352 |
|
| 701 | 1 |
_aGould _bD. J. |
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| 701 | 1 |
_aParakhonskiy _bB. V. |
|
| 701 | 1 |
_aSukhorukov _bG. B. _cchemist _cThe Head of the Laboratory of Tomsk Polytechnic University, Candidate of physical and mathematical sciences _f1969- _gGleb Borisovich _2stltpush _3(RuTPU)RU\TPU\pers\37353 |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bУправление проректора по научной работе и инновациям (НРиИ) _bЦентр RASA в Томске (Центр RASA) _bЛаборатория новых лекарственных форм (Лаб. НЛФ) _h7607 _2stltpush _3(RuTPU)RU\TPU\col\21677 |
| 801 | 2 |
_aRU _b63413507 _c20161003 _gRCR |
|
| 856 | 4 | _uhttp://dx.doi.org/10.1016/j.colsurfb.2016.05.090 | |
| 942 | _cCF | ||