| 000 | 04049nla2a2200373 4500 | ||
|---|---|---|---|
| 001 | 650516 | ||
| 005 | 20231030040952.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\15734 | ||
| 090 | _a650516 | ||
| 100 | _a20161007a2016 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 105 | _ay z 100zy | ||
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aIron oxide and gold nanoparticles in cancer therapy _fI. Gotman [et al.] |
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| 203 |
_aText _celectronic |
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| 300 | _aTitle screen | ||
| 320 | _a[References: 52 tit.] | ||
| 330 | _aContinuous research activities in the field of nanomedicine in the past decade have, to a great extent, been focused on nanoparticle technologies for cancer therapy. Gold and iron oxide nanoparticles (NP) are two of the most studied inorganic nanomaterials due to their unique optical and magnetic properties. Both types of NPs are emerging as promising systems for anti-tumor drug delivery and for nanoparticle-mediated thermal therapy of cancer. In thermal therapy, localized heating inside tumors or in proximity of tumor cells can be induced, for example, with Au NPs by radiofrequency ablation heating or conversion of photon energy (photothermal therapy) and in iron oxide magnetic NPs by heat generation through relaxation in an alternating magnetic field (magnetic hyperthermia). Furthermore, the superparamagnetic properties of iron oxide nanoparticles have led to their use as potent MRI (magnetic resonance imaging) contrast agents. Surface modification/coating can produce NPs with tailored and desired properties, such as enhanced blood circulation time, stability, biocompatibility and water solubility. To target nanoparticles to specific tumor cells, NPs should be conjugated with targeting moieties on the surface which bind to receptors or other molecular structures on the cell surface. The article presents several approaches to enhancing the specificity of Au and iron oxide nanoparticles for tumor tissue by appropriate surface modification/functionalization, as well as the effect of these treatments on the saturation magnetization value of iron oxide NPs. The use of other nanoparticles and nanostructures in cancer treatment is also briefly reviewed. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 | 0 |
_0(RuTPU)RU\TPU\network\4816 _tAIP Conference Proceedings |
|
| 463 | 0 |
_0(RuTPU)RU\TPU\network\17033 _tVol. 1760 : Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016 _oProceedings of the International conference, 22-25 March 2016, Tomsk, Russia _fNational Research Tomsk Polytechnic University (TPU) ; eds. E. Y. Gutmanas ; O. B. Naimark ; Yu. P. Sharkeev _v[020020, 6 p.] _d2016 |
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| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 701 | 1 |
_aGotman _bI. _gIrena |
|
| 701 | 1 |
_aPsakhie _bS. G. _cphysicist _chead of laboratory, Advisor to the rector, head of Department, Tomsk Polytechnic University, doctor of physico-mathematical Sciences _f1952- _gSergey Grigorievich _2stltpush _3(RuTPU)RU\TPU\pers\33038 |
|
| 701 | 1 |
_aLozhkomoev _bA. S. _cspecialist in the field of medical technology _cresearcher of Tomsk Polytechnic University _f1982- _gAleksandr Sergeevich _2stltpush _3(RuTPU)RU\TPU\pers\34706 |
|
| 701 | 1 |
_aGutmanas _bE. _gElazar |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bИнститут физики высоких технологий (ИФВТ) _bКафедра физики высоких технологий в машиностроении (ФВТМ) _bСетевая научно-образовательная лаборатория "Медицинское материаловедение" (СНОЛ ММ) _h7443 _2stltpush _3(RuTPU)RU\TPU\col\21275 |
| 801 | 2 |
_aRU _b63413507 _c20170120 _gRCR |
|
| 856 | 4 | _uhttp://dx.doi.org/10.1063/1.4960239 | |
| 856 | 4 | _uhttp://earchive.tpu.ru/handle/11683/35799 | |
| 942 | _cCF | ||