| 000 | 03306nlm1a2200445 4500 | ||
|---|---|---|---|
| 001 | 652156 | ||
| 005 | 20231030041128.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\17419 | ||
| 090 | _a652156 | ||
| 100 | _a20161202a2016 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aDesign, synthesis and evaluation of a new Mn – Contrast agent for MR imaging of myocardium based on the DTPA-phenylpentadecanoic acid complex _fM. L. Belyanin [et al.] |
|
| 203 |
_aText _celectronic |
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| 300 | _aTitle screen | ||
| 320 | _a[References: 48 tit.] | ||
| 330 | _aIn the present paper we describe the first synthesis and evaluation of a novel Mn (II) complex (DTPA-PPDA Mn (II)) which contains a C-15 fatty acid moiety that has high affinity to the heart muscle. The complexation energy of DTPA-PPDA Mn (II) evaluated by quantum chemistry methodology indicates that it essentially exceeds the corresponding value for the known DTPA Mn (II) complex. Molecular docking revealed that the affinity of the designed complex to the heart-type transport protein H-FABP well exceeds that of lauric acid. Phantom experiments in low-field MRI the designed contrast agent provides MR imaging comparable to gadopentetic acid. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 | _tChemical Physics Letters | ||
| 463 |
_tVol. 665 _v[P. 111-116] _d2016 |
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| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aконтрастное обнаружение | |
| 610 | 1 | _aДПФ | |
| 610 | 1 | _aмарганец | |
| 610 | 1 | _aгадолиний | |
| 701 | 1 |
_aBelyanin _bM. L. _corganic chemist _cAssociate Professor of Tomsk Polytechnic University, Candidate of chemical sciences _f1973- _gMaksim L'vovich _2stltpush _3(RuTPU)RU\TPU\pers\31268 |
|
| 701 | 1 |
_aStepanova _bE. V. _cchemist _cengineer of Tomsk Polytechnic University _f1978- _gElena Vladimirovna _2stltpush _3(RuTPU)RU\TPU\pers\34245 |
|
| 701 | 1 |
_aValiev _bR. R. _cchemist _cAssistant of Tomsk Polytechnic University _f1983- _gRashid Rinatovich _2stltpush _3(RuTPU)RU\TPU\pers\34114 |
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| 701 | 1 |
_aFilimonov _bV. D. _cRussian chemist _cProfessor of the TPU _f1945- _gViktor Dmitrievich _2stltpush _3(RuTPU)RU\TPU\pers\26423 |
|
| 701 | 1 |
_aUsov _bV. Yu. _gVladimir Yurjevich |
|
| 701 | 1 |
_aBorodin _bO. Yu. _gOleg Yurjevich |
|
| 701 | 1 |
_aHans _bA. _gAgren |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bИнститут физики высоких технологий (ИФВТ) _bКафедра биотехнологии и органической химии (БИОХ) _h6810 _2stltpush _3(RuTPU)RU\TPU\col\18693 |
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bИнститут физики высоких технологий (ИФВТ) _bКафедра общей химии и химической технологии (ОХХТ) _h7617 _2stltpush _3(RuTPU)RU\TPU\col\21253 |
| 801 | 2 |
_aRU _b63413507 _c20161202 _gRCR |
|
| 856 | 4 | _uhttp://dx.doi.org/10.1016/j.cplett.2016.10.058 | |
| 942 | _cCF | ||