| 000 | 03691nlm1a2200505 4500 | ||
|---|---|---|---|
| 001 | 652325 | ||
| 005 | 20231030041135.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\17609 | ||
| 035 | _aRU\TPU\network\17576 | ||
| 090 | _a652325 | ||
| 100 | _a20161219a2016 k y0engy50 ba | ||
| 101 | 1 |
_aeng _deng |
|
| 102 | _aUS | ||
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aModulation of Human Neutrophil Responses by the Essential Oils from Ferula akitschkensis and Their Constituents _fI. A. Schepetkin, S. V. Kushnarenko, G. Ozek [et al.] |
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| 203 |
_aText _celectronic |
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| 300 | _aTitle screen | ||
| 330 | _aEssential oils were obtained by hydrodistillation of the umbels+seeds and stems of Ferula akitschkensis (FAEOu/s and FAEOstm, respectively) and analyzed by gas chromatography and gas chromatography-mass spectrometry. Fifty-two compounds were identified in FAEOu/s; the primary components were sabinene, α-pinene, β-pinene, terpinen-4-ol, eremophilene, and 2-himachalen-7-ol, whereas the primary components of FAEOstm were myristicin and geranylacetone. FAEOu/s, β-pinene, sabinene, γ-terpinene, geranylacetone, isobornyl acetate, and (E)-2-nonenal stimulated [Ca2+]i mobilization in human neutrophils, with the most potent being geranylacetone (EC50 = 7.6 ± 1.9 μM) and isobornyl acetate 6.4 ± 1.7 (EC50 = 7.6 ± 1.9 μM). In addition, treatment of neutrophils with β-pinene, sabinene, γ-terpinene, geranylacetone, and isobornyl acetate desensitized the cells to N-formyl-Met-Leu-Phe (fMLF)- and interleukin-8 (IL-8)-induced [Ca2+]i flux and inhibited fMLF-induced chemotaxis. The effects of β-pinene, sabinene, γ-terpinene, geranylacetone, and isobornyl acetate on neutrophil [Ca2+]i flux were inhibited by transient receptor potential (TRP) channel blockers. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 |
_tJournal of Agricultural and Food Chemistry _d1953- |
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| 463 |
_tVol. 64, № 38 _v[P. 7156–7170] _d2016 |
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| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aэфирные масла | |
| 610 | 1 | _aчеловеческий организм | |
| 610 | 1 | _aреакции | |
| 701 | 1 |
_aSchepetkin (Shchepyotkin) _bI. A. _cdoctor-biophysicist _cleading researcher of Tomsk Polytechnic University, candidate of medical science _f1962- _gIgor Aleksandrovich _2stltpush _3(RuTPU)RU\TPU\pers\37358 |
|
| 701 | 1 |
_aKushnarenko _bS. V. _gSvetlana |
|
| 701 | 1 |
_aOzek _bG. _gGulmira |
|
| 701 | 1 |
_aKirpotina _bL. N. _gLiliya Nikolaevna |
|
| 701 | 1 |
_aSinharoy _bP. _gPritam |
|
| 701 | 1 |
_aUtegenova _bG. A. _gGulzhakhan |
|
| 701 | 1 |
_aAbidkulova _bK. T. _gKarime |
|
| 701 | 1 |
_aOzek _bT. _gTemel |
|
| 701 | 1 |
_aBaser _bK. H. C. _gKemal Husnu Can |
|
| 701 | 1 |
_aKovrizhina _bA. R. _cbiotechnology specialist _cResearch Engineer of Tomsk Polytechnic University _f1995- _gAnastasia Ruslanovna _2stltpush _3(RuTPU)RU\TPU\pers\46608 |
|
| 701 | 1 |
_aKhlebnikov _bA. I. _cChemist _cProfessor of Tomsk Polytechnic University _f1963- _gAndrey Ivanovich _2stltpush _3(RuTPU)RU\TPU\pers\33927 |
|
| 701 | 1 |
_aDamron _bD. S. _gDerek |
|
| 701 | 1 |
_aQuinn _bM. T. _gMark |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bИнститут физики высоких технологий (ИФВТ) _bКафедра биотехнологии и органической химии (БИОХ) _h6810 _2stltpush _3(RuTPU)RU\TPU\col\18693 |
| 801 | 2 |
_aRU _b63413507 _c20201103 _gRCR |
|
| 856 | 4 | _uhttp://dx.doi.org/10.1021/acs.jafc.6b03205 | |
| 942 | _cCF | ||