| 000 | 03080nam1a2200433 4500 | ||
|---|---|---|---|
| 001 | 652368 | ||
| 005 | 20231030041136.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\17652 | ||
| 090 | _a652368 | ||
| 100 | _a20161220a2016 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aMagnetic polymer-silica composites as bioluminescent sensors for bilirubin detection _fA. S. Timin [et al.] |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 320 | _a[References: 39 tit.] | ||
| 330 | _aThe synthesis of multifunctional nano-sized materials is leading to the rapid development of key application, including improved drug delivery, bioimaging and protein separation. In this work, magnetic silica particles modified with novel guanidine containing co-polymers were manufactured via sol-gel method. To evaluate the chemical composition of our prepared samples, FT-IR spectroscopy and thermogravimetry were conducted. Scanning electron microscopy was used in order to investigate the morphology of final products after modification by guanidine containing co-polymers and iron nanoparticles. In addition, the surface of polymer-silica composites was functionalized by the novel bilirubin-inducible fluorescent protein UnaG. In an aqueous bilirubin solution, the silica particles decorated with the polymer-UnaG have showed bright fluorescence. Synthesis and characterization of these hybrid materials allow developing of new multifunctional nano-sized materials, which will be used for detection and separation of bilirubin, a lipophilic heme catabolite that is a clinical diagnostic for liver function. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 | _tMaterials Chemistry and Physics | ||
| 463 |
_tVol. 183 _v[P. 422-429] _d2016 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aполимеры | |
| 610 | 1 | _aкремний | |
| 610 | 1 | _aкомпозиты | |
| 610 | 1 | _aбиолюминесцентный мониторинг | |
| 701 | 1 |
_aTimin _bA. S. _cChemist _cAssociate Scientist of Tomsk Polytechnic University _f1989- _gAleksandr Sergeevich _2stltpush _3(RuTPU)RU\TPU\pers\37036 |
|
| 701 | 1 |
_aSolomonov _bA. V. _gAlexey |
|
| 701 | 1 |
_aKumagai _bA. _gAkiko |
|
| 701 | 1 |
_aMiyawaki _bA. _gAtsushi |
|
| 701 | 1 |
_aKhashirova _bS. Yu. _gSvetlana |
|
| 701 | 1 |
_aZhansitov _bA. _gAzamat |
|
| 701 | 1 |
_aRumyantsev _bE. V. _gEvgeniy |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bУправление проректора по научной работе и инновациям (НРиИ) _bЦентр RASA в Томске _bЛаборатория новых лекарственных форм (Лаб. НЛФ) _h7607 _2stltpush _3(RuTPU)RU\TPU\col\21677 |
| 801 | 2 |
_aRU _b63413507 _c20161220 _gRCR |
|
| 856 | 4 | _uhttp://dx.doi.org/10.1016/j.matchemphys.2016.08.048 | |
| 942 | _cBK | ||