| 000 | 03508nlm0a2200457 4500 | ||
|---|---|---|---|
| 001 | 653279 | ||
| 005 | 20231030041215.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\18694 | ||
| 035 | _aRU\TPU\network\18592 | ||
| 090 | _a653279 | ||
| 100 | _a20170221d2016 k y0rusy50 ca | ||
| 101 | 0 | _aeng | |
| 102 | _aNL | ||
| 105 | _aa z 101zy | ||
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aRelationship between arterial blood pressure and blood viscosity in spontaneously hypertensive rats treated with pentoxifylline _fM. B. Plotnikov [et al.] |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 330 | _aBackground:Systemic arterial pressure (AP) depends on two physiological variables: cardiac output (CO) and total peripheral resistance (TPR). The latter depends on vascular hindrance and blood viscosity (BV). However, the relative contributions of the vascular and rheological factors to TPR remain unclear. Objective:The aim of our work was to study the haemodynamic and haemorheologic effects of a treatment course with pentoxifylline (PTX) in SHRs in an effort to assess the impact of the rheological factor on TPR and AP. Methods:The effects of the treatment course with PTX (100 mg/kg/day p.o. for six weeks) on BV, plasma viscosity, haematocrit, erythrocyte aggregation and deformability, mean AP (MAP), stroke volume (SV), CO, and TPR were studied in SHRs and in control Wistar Kyoto (WKY) rats. Results:PTX-treated SHRs had a lower BV, lower erythrocyte aggregation, and higher erythrocyte deformability index compared with the controls. The TPR level was higher by 43% compared with that in WKY rats and did not differ from the values obtained from control SHRs. In SHRs, moderate and strong positive correlations were found between BV and MAP and between BV and TPR. PTX-treated SHRs did not have any significant correlations between the above mentioned parameters. Conclusions:Treatment with PTX attenuated whole blood viscosity, but did not affect the AP and hemodynamic parameters in the experimental SHRs compared with the control SHRs. The magnitude of the rheologic effects of PTX was insufficient to cause appreciable decreases in TPR and AP. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 | _tBiorheology | ||
| 463 |
_tVol. 53, iss. 2 _v[P. 93-107] _d2016 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aпентоксифиллин | |
| 610 | 1 | _aартериальное давление | |
| 610 | 1 | _aвязкость | |
| 610 | 1 | _aкровь | |
| 701 | 1 |
_aPlotnikov _bM. B. |
|
| 701 | 1 |
_aAliev _bO. I. |
|
| 701 | 1 |
_aNosarev _bA. V. |
|
| 701 | 1 |
_aSidekhmenova _bA. V. |
|
| 701 | 1 |
_aAnfinogenova _bYa. J. _cLinguist _cLecturer of Tomsk Polytechnic University, Doctor of medical sciences _f1970- _gYana Jonovna _2stltpush _3(RuTPU)RU\TPU\pers\33592 |
|
| 701 | 1 |
_aAnishchenko _bA. M. |
|
| 701 | 1 |
_aPushkina _bE. V. |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bФизико-технический институт (ФТИ) _bКафедра иностранных языков физико-технического института (ИЯФТ) _h6715 _2stltpush _3(RuTPU)RU\TPU\col\18736 |
| 801 | 2 |
_aRU _b63413507 _c20170227 _gRCR |
|
| 856 | 4 | 0 | _uhttp://dx.doi.org/10.3233/BIR-15100 |
| 942 | _cCF | ||