| 000 | 02908nlm1a2200433 4500 | ||
|---|---|---|---|
| 001 | 653952 | ||
| 005 | 20231030041240.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\19467 | ||
| 035 | _aRU\TPU\network\19178 | ||
| 090 | _a653952 | ||
| 100 | _a20170404a2016 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 102 | _aDE | ||
| 135 | _adrgn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aExposure of nano- and ultrafine Ni particles to synthetic biological solutions: predicting fate-related dissolution and accumulation _fD. B. Abzhanova [et al.] |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 320 | _a[References: 33 tit.] | ||
| 330 | _aThe growing production and use of nickel (Ni) nanopowders with low biopersistence makes dissolution and accumulation degree in a body an important parameters needed for the risk assessment of nanoparticles. We propose an experimental approach for rapid determination of the dissolution degree of nanoscale (77 nm) and ultrafine (275 nm) Ni particles in synthetic biological solutions. It has been shown that after 2 h of exposure to simulating saliva and lysosomal liquid the dissolution degree of nanoparticles can reach 30 and 60 wt.%, respectively. With decreasing of the particle's size, they are characterized by increased solubility in saliva and the pulmonary tract; and the particles completely dissolve in 24 h. There was an attempt to predict the potential extent of accumulation of nickel compounds in the human body with particles entering the body by saliva or with breathing: with 3.8 times size decrease the probability of nickel accumulation in a body can rise in 3.5 times. | ||
| 461 | _tEuropean Journal of Nanomedicine | ||
| 463 |
_tVol. 8, iss. 4 _v[P. 203-212] _d2016 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aaccumulators | |
| 610 | 1 | _adissolution | |
| 610 | 1 | _aнакопления | |
| 610 | 1 | _aрастворение | |
| 610 | 1 | _aнаночастицы | |
| 610 | 1 | _aникель | |
| 701 | 1 |
_aAbzhanova _bD. B. _gDiana Beybitovna |
|
| 701 | 1 |
_aGodymchuk (Godimchuk) _bA. Yu. _cspecialist in the field of nanotechnologies and nanomaterials _cAssociate Professor of Tomsk Polytechnic University, candidate of technical science _f1978- _gAnna Yuryevna _2stltpush _3(RuTPU)RU\TPU\pers\29602 |
|
| 701 | 1 |
_aGusev _bA. A. _gAleksandr Anatoljevich |
|
| 701 | 1 |
_aKuznetsov _bD. V. _gDenis Valerjevich |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bИнститут физики высоких технологий (ИФВТ) _bКафедра наноматериалов и нанотехнологий (НМНТ) _h4572 _2stltpush _3(RuTPU)RU\TPU\col\18685 |
| 801 | 2 |
_aRU _b63413507 _c20170404 _gRCR |
|
| 856 | 4 | _uhttp://dx.doi.org/10.1515/ejnm-2016-0021 | |
| 942 | _cCF | ||