| 000 | 03062nlm1a2200469 4500 | ||
|---|---|---|---|
| 001 | 654102 | ||
| 005 | 20231030041246.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\19617 | ||
| 035 | _aRU\TPU\network\19437 | ||
| 090 | _a654102 | ||
| 100 | _a20170407a2016 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 102 | _aUS | ||
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aOptimizing the Heck–Matsuda Reaction in Flow with a Constraint-Adapted Direct Search Algorithm _fD. Cortes-Borda [et al.] |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 330 | _aThe optimization of a palladium-catalyzed Heck-Matsuda reaction using an optimization algorithm is presented. We modified and implemented the Nelder-Mead method in order to perform constrained optimizations in a multidimensional space. We illustrated the power of our modified algorithm through the optimization of a multivariable reaction involving the arylation of a deactivated olefin with an arenediazonium salt. The great flexibility of our optimization method allows to fine-tune experimental conditions according to three different objective functions: maximum yield, highest throughput, and lowest production cost. The beneficial properties of flow reactors associated with the power of intelligent algorithms for the fine-tuning of experimental parameters allowed the reaction to proceed in astonishingly simple conditions unable to promote the coupling through traditional batch chemistry. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 | _tOrganic Process Research and Development | ||
| 463 |
_tVol. 20, iss. 11 _v[P. 1979–1987] _d2016 |
||
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aреакция Хека | |
| 610 | 1 | _aалгоритмы оптимизации | |
| 610 | 1 | _aпалладий | |
| 610 | 1 | _aпроточные реакторы | |
| 610 | 1 | _aхимия | |
| 701 | 1 |
_aCortes-Borda _bD. _gDaniel |
|
| 701 | 1 |
_aKutonova _bK. V. _cchemist _cEngineer of Tomsk Polytechnic University _f1990- _gKsenia Valentinovna _2stltpush _3(RuTPU)RU\TPU\pers\31822 |
|
| 701 | 1 |
_aCorentin _bJ. _gJamet |
|
| 701 | 1 |
_aTrusova _bM. E. _corganic chemist _cAssociate professor of Tomsk Polytechnic University, Candidate of chemical sciences _f1982- _gMarina Evgenievna _2stltpush _3(RuTPU)RU\TPU\pers\31823 |
|
| 701 | 0 | _aZammattio Francoise | |
| 701 | 0 | _aTruchet Charlotte | |
| 701 | 0 | _aRodriguez-Zubiri Mireia | |
| 701 | 0 | _aFelpin Francois-Xavier | |
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bИнститут физики высоких технологий (ИФВТ) _bКафедра биотехнологии и органической химии (БИОХ) _h6810 _2stltpush _3(RuTPU)RU\TPU\col\18693 |
| 801 | 2 |
_aRU _b63413507 _c20170407 _gRCR |
|
| 856 | 4 | _uhttp://dx.doi.org/10.1021/acs.oprd.6b00310 | |
| 942 | _cCF | ||