| 000 | 03623nlm1a2200517 4500 | ||
|---|---|---|---|
| 001 | 654132 | ||
| 005 | 20231030041247.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\19659 | ||
| 035 | _aRU\TPU\network\14019 | ||
| 090 | _a654132 | ||
| 100 | _a20170412a2016 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 102 | _aUS | ||
| 135 | _adrnn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aLikelihood of mechanistic roles for dopaminergic, serotonergic and glutamatergic receptors in tardive dyskinesia: A comparison of genetic variants in two independent patient populations _fS. A. Ivanova [et al.] |
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| 203 |
_aText _celectronic |
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| 300 | _aTitle screen | ||
| 320 | _a[References: 49 tit.] | ||
| 330 | _aAn established theory for the pathogenesis of tardive dyskinesia is disturbed dopaminergic receptor sensitivity and/or dopaminergic intracellular signaling. We examined associations between genetic variants of neurotransmitter receptors and tardive dyskinesia. Methods: We assessed tardive dyskinesia in Caucasian psychiatric inpatients from Siberia (N = 431) and a long-stay population from the Netherlands (N = 168). These patients were genotyped for 43 tag single nucleotide polymorphisms in five neurotransmitter receptor genes, and the results for the two populations were compared. Results: Several significant associations with tardive dyskinesia were identified, but only GRIN2A (rs1345423) was found in both patient populations. This lack of agreement was probably due to the small effect size of the associations, the multiple testing and the small sample size of the Dutch patient population. After reviewing the literature, we propose that the constitutive stimulatory activity of serotonergic type 2 receptors may be relevant. Conclusions: Inactivity of the serotonergic, type 2C receptor or blockade of these receptors by atypical antipsychotic drugs may decrease the vulnerability to develop tardive dyskinesia. | ||
| 461 | _tSAGE Open Medicine | ||
| 463 |
_tVol. 4 _v[9 p.] _d2016 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aприемники | |
| 610 | 1 | _aантипсихотические препараты | |
| 610 | 1 | _aшизофрения | |
| 610 | 1 | _aнаркотические вещества | |
| 701 | 1 |
_aIvanova _bS. A. _cspecialist in the field of ecology and life safety _cProfessor of Tomsk Polytechnic University, doctor of medical sciences _f1964- _gSvetlana Aleksandrovna _2stltpush _3(RuTPU)RU\TPU\pers\33859 |
|
| 701 | 1 |
_aLoonen _bA. J. _gAnton |
|
| 701 | 1 |
_aBakker _bN. R. |
|
| 701 | 1 |
_aFreydin _bM. V. |
|
| 701 | 1 |
_aWoerds _bN. J. |
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| 701 | 1 |
_aHadithy _bA. FY Al. _gAsmar |
|
| 701 | 1 |
_aSemke _bA. V. _gArkady Valentinovich |
|
| 701 | 1 |
_aFedorenko _bO. Yu. _cspecialist in the field of ecology and life safety _cProfessor of Tomsk Polytechnic University, doctor of medical sciences _f1973- _gOlga Yurievna _2stltpush _3(RuTPU)RU\TPU\pers\33861 |
|
| 701 | 1 |
_aBrouwers _bJ. RBJ _gJacobus |
|
| 701 | 1 |
_aBokhan _bN. A. _gNikolay Aleksandrovich |
|
| 701 | 0 | _aJim van Os | |
| 701 | 0 | _aPeter N van Harten | |
| 701 | 1 |
_aWilffert _bB. _gBob |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bИнститут неразрушающего контроля (ИНК) _bКафедра экологии и безопасности жизнедеятельности (ЭБЖ) _h4850 _2stltpush _3(RuTPU)RU\TPU\col\18720 |
| 801 | 2 |
_aRU _b63413507 _c20170412 _gRCR |
|
| 856 | 4 | _uhttp://dx.doi.org/10.1177/2050312116643673 | |
| 942 | _cCF | ||