| 000 | 03604nlm1a2200505 4500 | ||
|---|---|---|---|
| 001 | 654150 | ||
| 005 | 20231030041248.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\19677 | ||
| 035 | _aRU\TPU\network\13970 | ||
| 090 | _a654150 | ||
| 100 | _a20170413a2016 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aIdentification of 5-hydroxytryptamine receptor gene polymorphisms modulating hyperprolactinaemia in antipsychotic drug-treated patients with schizophrenia _fS. A. Ivanova [et al.] |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 320 | _a[References: p. 245-246 (42 tit.)] | ||
| 330 | _aObjectives: Hyperprolactinaemia (HPRL) is a classical side effect of antipsychotic drugs primarily attributed to blockade of dopamine D2 subtype receptors in the pituitary gland. Although dopamine is considered the primary factor inhibiting prolactin release, the activity of prolactin-producing lactotrophs is also regulated by the secretagogues thyrotrophin releasing hormone, vasoactive intestinal polypeptide and serotonin (5-hydroxytryptamine; 5-HT). Methods: We describe the association between HPRL and a set of 29 SNPs from 5-HT receptor genes HTR1A, HTR1B, HTR2A, HTR2C, HTR3A, HTR3B and HTR6 in a population of 446 Caucasians (221 males/225 females) with a clinical diagnosis of schizophrenia (according to ICD-10: F20) who were treated with classical and/or atypical antipsychotic drugs. Results: None of the studied autosomal markers were found to be associated with HPRL. However, a significant association was established between various HTR2C polymorphisms and HPRL. Conclusions: This study revealed an association between HPRL and X-chromosome haplotypes comprised of the rs569959 and rs17326429 polymorphisms. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 | _tThe World Journal of Biological Psychiatry | ||
| 463 |
_tVol. 18, iss. 3 _v[P. 239-246] _d2016 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _apolymorphism | |
| 610 | 1 | _aantipsychotics | |
| 610 | 1 | _aschizophrenia | |
| 610 | 1 | _aполиморфизм | |
| 610 | 1 | _aшизофрения | |
| 701 | 1 |
_aIvanova _bS. A. _cspecialist in the field of ecology and life safety _cProfessor of Tomsk Polytechnic University, doctor of medical sciences _f1964- _gSvetlana Aleksandrovna _2stltpush _3(RuTPU)RU\TPU\pers\33859 |
|
| 701 | 1 |
_aOsmanova _bD. Z. _gDiana |
|
| 701 | 1 |
_aFreydin _bM. V. |
|
| 701 | 1 |
_aFedorenko _bO. Yu. _cspecialist in the field of ecology and life safety _cProfessor of Tomsk Polytechnic University, doctor of medical sciences _f1973- _gOlga Yurievna _2stltpush _3(RuTPU)RU\TPU\pers\33861 |
|
| 701 | 1 |
_aBoyko _bA. S. _gAnastasiya Sergeevna |
|
| 701 | 1 |
_aPozhidaev _bI. V. _gIvan |
|
| 701 | 1 |
_aSemke _bA. V. _gArkady Valentinovich |
|
| 701 | 1 |
_aBokhan _bN. A. _gNikolay Aleksandrovich |
|
| 701 | 1 |
_aAgarkov _bA. A. _gAleksey Aleksandrovich |
|
| 701 | 1 |
_aVilffert _bB. _gBob |
|
| 701 | 1 |
_aLoonen _bA. J. M. _gAnton |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bИнститут неразрушающего контроля (ИНК) _bКафедра экологии и безопасности жизнедеятельности (ЭБЖ) _h4850 _2stltpush _3(RuTPU)RU\TPU\col\18720 |
| 801 | 2 |
_aRU _b63413507 _c20170413 _gRCR |
|
| 856 | 4 | _uhttp://dx.doi.org/10.1080/15622975.2016.1224926 | |
| 942 | _cCF | ||