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| 001 | 654748 | ||
| 005 | 20231030041314.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\20434 | ||
| 035 | _aRU\TPU\network\20404 | ||
| 090 | _a654748 | ||
| 100 | _a20170518d2016 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 102 | _aHR | ||
| 105 | _ay z 000zy | ||
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aCircuits Regulating Pleasure and Happiness: A Focus on Addiction, Beyond the Ventral Striatum _fAnton J.M. Loonen, Arnt F.A. Schellekens, Svetlana A. Ivanova _hChapter 1 |
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| 203 |
_aText _celectronic |
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| 300 | _aTitle screen | ||
| 320 | _a[References: p. 16-20 (57 tit.)] | ||
| 330 | _aA recently developed anatomical model describes how the intensity of reward-seeking and misery-fleeing behaviours is regulated. The first type of behaviours is regulated within an extrapyramidal cortical-subcortical circuit containing as first relay stations, the caudate nucleus, putamen and core of the accumbens nucleus. The second type of behaviours is controlled by a limbic cortical-subcortical circuit with as first stations, the centromedial amygdala, extended amygdala, bed nucleus of the stria terminalis and shell of the accumbens nucleus. We hypothesize that sudden cessation of hyperactivity of the first circuit results in feelings of pleasure and of the second circuit in feelings of happiness. The insular cortex has probably an essential role in the perception of these and other emotions. Motivation to show these behaviours is regulated by monoaminergic neurons projecting to the accumbens from the midbrain: dopaminergic ventral tegmental nuclei, adrenergic locus coeruleus and serotonergic upper raphe nuclei. The activity of these monoaminergic nuclei is in turn regulated through a ventral pathway by the prefrontal cortex and through a dorsal pathway by the medial and lateral habenula. The habenula has this role since the first vertebrate human ancestors with a brain comparable to that of modern lampreys. The lateral habenula promotes or inhibits reward-seeking behaviours depending upon the gained reward being larger or smaller than expected. It is suggested that the ventral pathway is essential for maintaining addiction based on the observation of specific cues, while the dorsal pathway is essential for becoming addicted and relapsing during periods of abstinence. | ||
| 463 |
_tRecent Advances in Drug Addiction Research and Clinical Applications _feds. W. M. Meil, C. L. Ruby _v[P. 1-20] _d2016 |
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| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aнаркомания | |
| 610 | 1 | _aнастроение | |
| 610 | 1 | _aбазальные ганглии | |
| 610 | 1 | _aамигдала | |
| 610 | 1 | _aинсула | |
| 610 | 1 | _aгабенула | |
| 700 | 1 |
_aLoonen _bA. J. M. _gAnton J. M. |
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| 701 | 1 |
_aSchellekens _bA. F. A. _gArnt F. A. |
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| 701 | 1 |
_aIvanova _bS. A. _cspecialist in the field of ecology and life safety _cProfessor of Tomsk Polytechnic University, doctor of medical sciences _f1964- _gSvetlana Aleksandrovna _2stltpush _3(RuTPU)RU\TPU\pers\33859 |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bИнститут неразрушающего контроля (ИНК) _bКафедра экологии и безопасности жизнедеятельности (ЭБЖ) _h4850 _2stltpush _3(RuTPU)RU\TPU\col\18720 |
| 801 | 1 |
_aRU _b63413507 _c20141010 |
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| 801 | 2 |
_aRU _b63413507 _c20170518 _gRCR |
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| 856 | 4 | _uhttp://dx.doi.org/10.5772/62707 | |
| 856 | 4 | 0 | _uhttps://www.intechopen.com/books/recent-advances-in-drug-addiction-research-and-clinical-applications/circuits-regulating-pleasure-and-happiness-a-focus-on-addiction-beyond-the-ventral-striatum |
| 942 | _cCF | ||