| 000 | 03214nlm1a2200445 4500 | ||
|---|---|---|---|
| 001 | 655541 | ||
| 005 | 20231030041348.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\21728 | ||
| 035 | _aRU\TPU\network\21727 | ||
| 090 | _a655541 | ||
| 100 | _a20170911a2017 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aNeurohumoral markers that predict the efficiency of pharmacologic therapy of depressive disorders _fL. A. Levchuk [et al.] |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 320 | _a[References: 16 tit.] | ||
| 330 | _aWe present a comprehensive clinical and biological study of 46 patients with depressive disorder (F32-F33: depressive episode and recurrent depressive disorder) during pharmacotherapy. Neurohumoral factors (cortisol, brain-derived neurotrophic factor, serotonin, DHEA and its sulfated form) were determined in serum by ELISA. The severity of the current depressive episode was evaluated using the 17-point Hamilton Depression Rating Scale (HDRS-17); the pharmacotherapy efficacy was evaluated using the scale of the Clinical Global Impression (CGI Scale). We showed that before prescription of pharmacotherapy peripheral blood neurohumoral markers that characterize the state of stress-realizing and stress-limiting systems of the body may be considered as biological predictors of the effective pharmacotherapy of a current depressive episode and used as additional paraclinical examination methods. At higher concentrations of cortisol and serotonin associated with a decrease in the content of neurosteroid dehydroepiandrosterone, the high efficiency of the pharmacotherapy of depressive episode is predicted. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 | _tNeurochemical Journal | ||
| 463 |
_tVol. 11, iss. 2 _v[P. 185–187] _d2017 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _adepressive disorder | |
| 610 | 1 | _apharmacotherapy | |
| 610 | 1 | _aneurohumoral system | |
| 610 | 1 | _aдепрессивные расстройства | |
| 610 | 1 | _aнейрогуморальные системы | |
| 610 | 1 | _aфармакотерапия | |
| 701 | 1 |
_aLevchuk _bL. A. _gLyudmila Aleksandrovna |
|
| 701 | 1 |
_aVyalova _bN. M. _gNataljya Mikhaylovna |
|
| 701 | 1 |
_aSimutkin _bG. G. _gGerman Gennadjevich |
|
| 701 | 1 |
_aBokhan _bN. A. _gNikolay Aleksandrovich |
|
| 701 | 1 |
_aIvanova _bS. A. _cspecialist in the field of ecology and life safety _cProfessor of Tomsk Polytechnic University, doctor of medical sciences _f1964- _gSvetlana Aleksandrovna _2stltpush _3(RuTPU)RU\TPU\pers\33859 |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bИнститут неразрушающего контроля (ИНК) _bКафедра экологии и безопасности жизнедеятельности (ЭБЖ) _h4850 _2stltpush _3(RuTPU)RU\TPU\col\18720 |
| 801 | 2 |
_aRU _b63413507 _c20170911 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.1134/S1819712417020088 | |
| 942 | _cCF | ||