| 000 | 03629nlm1a2200409 4500 | ||
|---|---|---|---|
| 001 | 655926 | ||
| 005 | 20231030041406.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\22266 | ||
| 090 | _a655926 | ||
| 100 | _a20171012a2017 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aPolylactic Acid Sealed Polyelectrolyte Multilayer Microchambers for Entrapment of Salts and Small Hydrophilic Molecules Precipitates _fM. Gai, J. C. Frueh, V. L. Kudryavtseva [et al.] |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 330 | _aEfficient depot systems for entrapment and storage of small water-soluble molecules are of high demand for wide variety of applications ranging from implant based drug delivery in medicine and catalysis in chemical processes to anticorrosive systems in industry where surface-mediated active component delivery is required on a time and site specific manner. This work reports the fabrication of individually sealed hollow-structured polyelectrolyte multilayer (PEM) microchamber arrays based on layer-by-layer self-assembly as scaffolds and microcontact printing. These PEM chambers are composed out of biocompatible polyelectrolytes and sealed by a monolayer of hydrophobic biocompatible and biodegradable polylactic acid (PLA). Coating the chambers with hydrophobic PLA allows for entrapment of a microair-bubble in each chamber that seals and hence drastically reduces the PEM permeability. PLA@PEM microchambers are proven to enable prolonged subaqueous storage of small hydrophilic salts and molecules such as crystalline NaCl, doxicycline, and fluorescent dye rhodamine B. The presented microchambers are able to entrap air bubbles and demonstrate a novel strategy for entrapment, storage, and protection of micropackaged water-soluble substances in precipitated form. These chambers allow triggered release as demonstrated by ultrasound responsiveness of the chambers. Low-frequency ultrasound exposure is utilized for microchamber opening and payload release. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 | _tACS Applied Materials & Interfaces | ||
| 463 |
_tVol. 9, iss. 19 _v[P. 16536-16545] _d2017 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aвоздушные пузырьки | |
| 610 | 1 | _aконтролируемые атмосферы | |
| 610 | 1 | _aгидрофобизация | |
| 610 | 1 | _aполиэлектролиты | |
| 610 | 1 | _aстимулы | |
| 701 | 1 |
_aGai _bM. _gMeiyu |
|
| 701 | 1 |
_aFrueh _bJ. С. _cspecialist in the field of medical technology _cResearcher of Tomsk Polytechnic University, Ph.D _f1983- _gJohannes Christoph _2stltpush _3(RuTPU)RU\TPU\pers\47197 |
|
| 701 | 1 |
_aKudryavtseva _bV. L. _cphysicist _cEngineer of Tomsk Polytechnic University _f1993- _gValeriya Lvovna _2stltpush _3(RuTPU)RU\TPU\pers\38564 |
|
| 701 | 1 |
_aYashchenok _bA. M. _gAlexey |
|
| 701 | 1 |
_aSukhorukov _bG. B. _gGleb Borisovich |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bУправление проректора по научной работе и инновациям (НРиИ) _bЦентр RASA в Томске _bЛаборатория изучения механизмов нейропротекции (Лаб. ИМН) _h7608 _2stltpush _3(RuTPU)RU\TPU\col\21815 |
| 801 | 2 |
_aRU _b63413507 _c20220520 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.1021/acsami.7b03451 | |
| 942 | _cCF | ||