| 000 | 03295nlm1a2200493 4500 | ||
|---|---|---|---|
| 001 | 656612 | ||
| 005 | 20231030041436.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\23053 | ||
| 035 | _aRU\TPU\network\22624 | ||
| 090 | _a656612 | ||
| 100 | _a20171123a2014 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aIonic Mechanisms of Carbon Monoxide Action on the Contractile Properties of the Vascular Smooth Muscles _fM. B. Baskakov [et al.] |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 330 | _aCarbon monoxide (CO) is one of a family of gas transmitters. In this article, we present the results of mechanographic investigations of the mechanisms of CO action on rat thoracic aorta segments. We have found that relaxing effect of CORM-2, CO donor, on vascular smooth muscles was mediated mainly by opening of voltage-gated potassium channels in smooth muscle cells: 4-aminopyridine, blocking these channels, almost completely eliminated CO-induced vasorelaxation of the segments precontracted by depolarization of the smooth muscle cell membranes with high potassium (30 mM KCl) solution or by phenylephrine (10 mM). For the first time, we have documented that CORM-2 reduces the nicardipine-sensitive input of45 Ca2+ in freshly isolated aorta cells. There are reasons to suppose that the L-type voltage-gated calcium channels of the vascular smooth muscle cells are another CO target for the relaxing effect of this gas transmitter. Additional studies are required to determine the influence of ruthenium complexes (Ru(II)) on phenomenology of carbon monoxide effects. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 | _tInternational Journal of Physiology and Pathophysiology | ||
| 463 |
_tVol. 5, iss. 2 _v[P. 141-149] _d2014 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aмонооксид углерода | |
| 610 | 1 | _aгладкие мышцы | |
| 610 | 1 | _aсосуды | |
| 610 | 1 | _aкалиевые каналы | |
| 610 | 1 | _acarbon monoxide | |
| 610 | 1 | _avascular smooth muscles | |
| 610 | 1 | _apotassium channels | |
| 610 | 1 | _aL-type calcium channels | |
| 701 | 1 |
_aBaskakov _bM. B. _gMikhail Borisovich |
|
| 701 | 1 |
_aZheludeva _bA. B. _gAnastasiya Sergeevna |
|
| 701 | 1 |
_aGusakova _bS. V. _gSvetlana Valerjevna |
|
| 701 | 1 |
_aSmagliy _bL. V. _gLyudmila Vyacheslavovna |
|
| 701 | 1 |
_aAleinik _bA. N. _cphysicist _cSenior researcher of Tomsk Polytechnic University, Candidate of physical and mathematical science _f1944- _gAleksandr Nikonorovich _2stltpush _3(RuTPU)RU\TPU\pers\31074 |
|
| 701 | 1 |
_aYanchuk _bP. _gPetro |
|
| 701 | 1 |
_aMedvedev _bM. A. _gMikhail Andreevich |
|
| 701 | 1 |
_aOrlov _bS. N. _gSergey Nikolaevich |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bФизико-технический институт (ФТИ) _bКафедра прикладной физики (№ 12) (ПФ) _h46 _2stltpush _3(RuTPU)RU\TPU\col\18729 |
| 801 | 2 |
_aRU _b63413507 _c20171123 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.1615/IntJPhysPathophys.v5.i2.50 | |
| 942 | _cCF | ||