| 000 | 03133nlm1a2200445 4500 | ||
|---|---|---|---|
| 001 | 656683 | ||
| 005 | 20231030041439.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\23149 | ||
| 090 | _a656683 | ||
| 100 | _a20171205a2017 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 102 | _aUS | ||
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aSearch for genetic markers of climatic adaptation in populations of North Eurasia _fV. A. Stepanov [et al.] |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 320 | _a[References: 40 tit.] | ||
| 330 | _aGenetic diversity of native populations of North Eurasia is investigated using a panel of genetic markers of candidate genes for cold climate adaptation. A high level of within- and between-population variability is detected. Comparative analysis of data on North Eurasian populations combined with data on worldwide populations from the 1000 Genomes and HDGP projects reveals correlations of genetic diversity in candidate genes for cold climate adaptation with key climate parameters, as well as the increase of genetic diversity in markers of this group of genes with the increase of latitude, that is, as modern humans migrated out of Africa. Using the method of searching for extreme empirical values of the coefficient of genetic diversity, signals of directional selection for markers of six genes adaptive to cold (MYOF, LONP2, IFNL4, MKL1, SLC2A12, and CPT1A) are found. The data are discussed in framework of the hypothesis of decanalization of genome–phenome relationships under the pressure of natural selection during human settlement throughout the world. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 | _tRussian Journal of Genetics | ||
| 463 |
_tVol. 53, iss. 11 _v[P. 1172-1183] _d2017 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aадаптация | |
| 610 | 1 | _aестественный отбор | |
| 610 | 1 | _aнаселение | |
| 610 | 1 | _aгенетическое содержание | |
| 701 | 1 |
_aStepanov _bV. A. _gVadim Anatoljevich |
|
| 701 | 1 |
_aKharkov _bV. N. _gVladimir Nikolaevich |
|
| 701 | 1 |
_aVagaytseva _bK. V. _gKseniya Valerjevna |
|
| 701 | 1 |
_aBocharova _bA. V. _gAnna Vladimirovna |
|
| 701 | 1 |
_aKazantsev _bA. Yu. _clinguist _cAssociate Professor of Tomsk Polytechnic University, candidate of philological sciences _f1971- _gAndrey Yurievich _2stltpush _3(RuTPU)RU\TPU\pers\38724 |
|
| 701 | 1 |
_aPopovich _bA. A. _gAnastasiya Andreevna |
|
| 701 | 1 |
_aKhitrinskaya _bI. Yu. _gIrina Yurjevna |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bФизико-технический институт (ФТИ) _bКафедра иностранных языков физико-технического института (ИЯФТ) _h6715 _2stltpush _3(RuTPU)RU\TPU\col\18736 |
| 801 | 2 |
_aRU _b63413507 _c20171220 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.1134/S1022795417110114 | |
| 942 | _cCF | ||