| 000 | 05793nlm1a2200637 4500 | ||
|---|---|---|---|
| 001 | 656731 | ||
| 005 | 20231030041442.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\23197 | ||
| 090 | _a656731 | ||
| 100 | _a20171208a2017 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aAtmospheric pressure plasma assisted immobilization of hyaluronic acid on tissue engineering PLA-based scaffolds and its effect on primary human macrophages _fV. L. Kudryavtseva, K. S. Stankevich, A. Gudima [et al.] |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 320 | _a[References: p. 270-271 (80 tit.)] | ||
| 330 | _aBioactive polylactic acid based (PLA) scaffolds with hyaluronic acid immobilized on their surface by atmospheric pressure plasma assisted modification method were developed. By using X-ray photoelectron spectroscopy and wettability measurements it was shown that atmospheric pressure plasma treatment leads to the changes in surface chemical composition of the PLA-based scaffolds that resulted in an increased long-term hydrophilicity of the scaffolds surface. Scanning electron microscopy and mechanical studies revealed that the use of plasma for surface activation allows for the non-destructive immobilization of bioactive compounds like hyaluronic acid. The modified PLA-based scaffolds effect on the release of cytokines and matrix metalloproteinases by primary human monocyte-derived macrophages was investigated. The macrophages reaction to the scaffolds was donor-specific, however, the two best materials from immunological point of view were identified - plasma treated PLA-based scaffold and PLA-based scaffold with the least amount of immobilized hyaluronic acid. Both hyaluronic acid attachment and atmospheric pressure plasma treatment enhance PLA-based scaffolds biocompatibility. It was found that supernatants collected after the macrophages coculture with modified PLA-based scaffolds stimulate HUVECs' tube formation. The modified PLA-based scaffolds possess pro-angiogenic activity. Thus, our research offers a high-performing method for the creation of polymer-based tissue engineering scaffolds with modified bioactive surface. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 |
_tMaterials and Design _d1978- |
||
| 463 |
_tVol. 127 _v[P. 261-271] _d2017 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _apolylactic acid (PLA) | |
| 610 | 1 | _ahyaluronic acid (HA) | |
| 610 | 1 | _atissue engineering scaffold (TES) | |
| 610 | 1 | _aplasma | |
| 610 | 1 | _amacrophages | |
| 610 | 1 | _acytokines | |
| 610 | 1 | _aполимолочная кислота | |
| 610 | 1 | _aгиалуроновая кислота | |
| 610 | 1 | _aплазма | |
| 610 | 1 | _aмакрофаги | |
| 610 | 1 | _aцитокины | |
| 701 | 1 |
_aKudryavtseva _bV. L. _cphysicist _cEngineer of Tomsk Polytechnic University _f1993- _gValeriya Lvovna _2stltpush _3(RuTPU)RU\TPU\pers\38564 |
|
| 701 | 1 |
_aStankevich _bK. S. _cPhysicist _cEngineer Tomsk Polytechnic University _f1992- _gKsenia Sergeevna _2stltpush _3(RuTPU)RU\TPU\pers\37546 |
|
| 701 | 1 |
_aGudima _bA. _gAleksandru |
|
| 701 | 1 |
_aKibler _bE. V. _cspecialist in the field of nuclear technologies _cEngineer of Tomsk Polytechnic University _f1995- _gElina Vitaljevna _2stltpush _3(RuTPU)RU\TPU\pers\46672 |
|
| 701 | 1 |
_aZhukov _bYu. N. _gYury Nikolaevich |
|
| 701 | 1 |
_aBolbasov _bE. N. _cphysicist _cEngineer of Tomsk Polytechnic University _f1981- _gEvgeny Nikolaevich _2stltpush _3(RuTPU)RU\TPU\pers\30857 |
|
| 701 | 1 |
_aMalashicheva _bA. B. _gAnna Borisovna |
|
| 701 | 1 |
_aZhuravlev _bM. V. _cphysicist _cengineer-researcher of Tomsk Polytechnic University _f1986- _gMikhail Valerievich _2stltpush _3(RuTPU)RU\TPU\pers\34637 |
|
| 701 | 1 |
_aRyabov _bV. B. _gVladimir Borisovich |
|
| 701 | 1 |
_aLiu _bT. _gTengfei |
|
| 701 | 1 |
_aFilimonov _bV. D. _cRussian chemist _cProfessor of the TPU _f1945- _gViktor Dmitrievich _2stltpush _3(RuTPU)RU\TPU\pers\26423 |
|
| 701 | 1 |
_aRemnev _bG. E. _cphysicist _cProfessor of Tomsk Polytechnic University, Doctor of technical sciences _f1948- _gGennady Efimovich _2stltpush _3(RuTPU)RU\TPU\pers\31500 |
|
| 701 | 1 |
_aKluter _bH. _gHaralg |
|
| 701 | 1 |
_aKzhyshkowska _bJu. _gJulia |
|
| 701 | 1 |
_aTverdokhlebov _bS. I. _cphysicist _cAssociate Professor of Tomsk Polytechnic University, Candidate of physical and mathematical science _f1961- _gSergei Ivanovich _2stltpush _3(RuTPU)RU\TPU\pers\30855 |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bУправление проректора по научной работе и инновациям (НРиИ) _bЦентр RASA в Томске _bЛаборатория изучения механизмов нейропротекции (Лаб. ИМН) _h7608 _2stltpush _3(RuTPU)RU\TPU\col\21815 |
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bИнститут физики высоких технологий (ИФВТ) _bКафедра биотехнологии и органической химии (БИОХ) _h6810 _2stltpush _3(RuTPU)RU\TPU\col\18693 |
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bФизико-технический институт (ФТИ) _bКафедра экспериментальной физики (ЭФ) _h7596 _2stltpush _3(RuTPU)RU\TPU\col\21255 |
| 801 | 2 |
_aRU _b63413507 _c20201119 _gRCR |
|
| 856 | 4 | 0 | _uhttps://doi.org/10.1016/j.matdes.2017.04.079 |
| 942 | _cCF | ||