| 000 | 03417nlm1a2200493 4500 | ||
|---|---|---|---|
| 001 | 657097 | ||
| 005 | 20231030041457.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\23577 | ||
| 035 | _aRU\TPU\network\23264 | ||
| 090 | _a657097 | ||
| 100 | _a20171229a2017 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 102 | _aUS | ||
| 135 | _aarcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aChemical composition and phagocyte immunomodulatory activity of Ferula iliensis essential oils _fG. Ozek [et al.] |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 330 | _aEssential oil extracts from Ferula iliensis have been used traditionally in Kazakhstan for treatment of inflammation and other illnesses. Because little is known about the biologic activity of these essential oils that contributes to their therapeutic properties, we analyzed their chemical composition and evaluated their phagocyte immunomodulatory activity. The main components of the extracted essential oils were (E)-propenyl sec-butyl disulfide (15.7–39.4%) and (Z)-propenyl sec-butyl disulfide (23.4–45.0%). Ferula essential oils stimulated [Ca2+]i mobilization in human neutrophils and activated ROS production in human neutrophils and murine bone marrow phagocytes. Activation of human neutrophil [Ca2+]i flux by Ferula essential oils was dose-dependently inhibited by capsazepine, a TRPV1 channel antagonist, indicating that TRPV1 channels mediate this response. Furthermore, Ferula essential oils stimulated Ca2+ influx in TRPV1 channel–transfected HEK293 cells and desensitized the capsaicin-induced response in these cells. Additional molecular modeling with known TRPV1 channel agonists suggested that the active component is likely to be (Z)-propenyl sec-butyl disulfide. Our results provide a cellular and molecular basis to explain at least part of the beneficial therapeutic properties of FEOs. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 | _tJournal of Leukocyte Biology | ||
| 463 |
_tVol. 101, iss. 6 _v[P. 1361-1371] _d2017 |
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| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aхимический состав | |
| 610 | 1 | _aфагоциты | |
| 701 | 1 |
_aOzek _bG. _gGulmira |
|
| 701 | 1 |
_aShchepetkin _bI. A. _gIgor Alexandrovitch |
|
| 701 | 1 |
_aUtegenova _bG. A. _gGulzhakhan A. |
|
| 701 | 1 |
_aKirpotina _bL. N. _gLiliya Nikolaevna |
|
| 701 | 1 |
_aSpencer _bA. R. _gAndrei |
|
| 701 | 1 |
_aOzek _bT. _gTemel |
|
| 701 | 0 | _aBaser Kemal Husnu Can | |
| 701 | 1 |
_aAbidkulova _bK. T. _gKarime |
|
| 701 | 1 |
_aKushnarenko _bS. V. _gSvetlana Veniaminovna |
|
| 701 | 1 |
_aKhlebnikov _bA. I. _cChemist _cProfessor of Tomsk Polytechnic University _f1963- _gAndrey Ivanovich _2stltpush _3(RuTPU)RU\TPU\pers\33927 |
|
| 701 | 1 |
_aDamron _bD. S. _gDerek |
|
| 701 | 1 |
_aQuinn _bM. T. _gQuinn |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bИнститут физики высоких технологий (ИФВТ) _bКафедра биотехнологии и органической химии (БИОХ) _h6810 _2stltpush _3(RuTPU)RU\TPU\col\18693 |
| 801 | 1 |
_aRU _b63413507 _c20110823 |
|
| 801 | 2 |
_aRU _b63413507 _c20171229 _gRCR |
|
| 856 | 4 | 0 | _uhttps://doi.org/10.1189/jlb.3A1216-518RR |
| 942 | _cCF | ||