| 000 | 03779nlm1a2200469 4500 | ||
|---|---|---|---|
| 001 | 657242 | ||
| 005 | 20231030041502.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\23744 | ||
| 035 | _aRU\TPU\network\11964 | ||
| 090 | _a657242 | ||
| 100 | _a20180122a2017 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aComparative Study of Genotoxicity of Silver and Gold Nanoparticles Prepared by the Electric Spark Dispersion Method _fE. V. Plotnikov, S. P. Zhuravkov, A. B. Gapeyev [et al.] |
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| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 320 | _a[References: p. 38-39 (33 tit.)] | ||
| 330 | _aObjective: There is plenty of information dedicated to nanomaterial toxicity, but it is often contradictory. This work presents results of the comparative investigation of silver and gold nanoparticles genotoxicity and genotoxic effect of water medium after the spark dispersion process. Material and methods: The nanoparticles were produced in water by the modified energy-efficient electric spark dispersion method. The comet assay, transmission electron microscopy, DLS spectroscopy and thermal desorption of nitrogen (BET method) were used for the investigation. Results: The silver nanoparticles showed a genotoxic effect which appeared at concentration of 0.03 mg/ml and above. The application of gold nanoparticles did not lead to a significant DNA damage at concentrations range of 0.01 - 0.03 mg/ml. However, a notable level of genotoxicity was observed at concentrations of gold nanoparticles about 0.1 mg/ml. Supernatant water medium (with trace of Au and Ag metals) following the spark dispersion process showed no genotoxic action. Conclusion: Accordingly, the testing of the nanoparticles produced by the electric spark dispersion in water revealed more expressed genotoxic effect of silver nanoparticles in comparison with the gold ones. | ||
| 461 | _tJournal of Applied Pharmaceutical Science | ||
| 463 |
_tVol. 7 (7) _v[P. 35-39] _d2017 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aгенотоксичность | |
| 610 | 1 | _aнаночастицы | |
| 610 | 1 | _aсеребро | |
| 610 | 1 | _aдисперсия | |
| 610 | 1 | _aзолото | |
| 610 | 1 | _aлейкоциты | |
| 701 | 1 |
_aPlotnikov _bE. V. _cchemist _cEngineer of Tomsk Polytechnic University _f1983- _gEvgeny Vladimirovich _2stltpush _3(RuTPU)RU\TPU\pers\32469 |
|
| 701 | 1 |
_aZhuravkov _bS. P. _cchemist _cSenior researcher of Tomsk Polytechnic University, Candidate of chemical sciences _f1961- _gSergey Petrovich _2stltpush _3(RuTPU)RU\TPU\pers\31297 |
|
| 701 | 1 |
_aGapeyev _bA. B. _gAndrew |
|
| 701 | 1 |
_aPlotnikov _bV. M. _gVladimir Mikhaylovich |
|
| 701 | 1 |
_aMartemjyanova _bI. V. _gIrina Vladimirovna |
|
| 701 | 1 |
_aMartemyanov _bD. V. _cchemist _cEngineer-researcher of Tomsk Polytechnic University _f1978- _gDmitry Vladimirovich _2stltpush _3(RuTPU)RU\TPU\pers\31283 |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bИнститут природных ресурсов (ИПР) _bКафедра физической и аналитической химии (ФАХ) _h94 _2stltpush _3(RuTPU)RU\TPU\col\18656 |
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bИнститут физики высоких технологий (ИФВТ) _bЛаборатория № 12 _h6389 _2stltpush _3(RuTPU)RU\TPU\col\19054 |
| 801 | 2 |
_aRU _b63413507 _c20230201 _gRCR |
|
| 856 | 4 | _uhttp://earchive.tpu.ru/handle/11683/65320 | |
| 856 | 4 | _uhttps://doi.org/10.7324/JAPS.2017.70705 | |
| 942 | _cCF | ||