| 000 | 03674nlm1a2200409 4500 | ||
|---|---|---|---|
| 001 | 657383 | ||
| 005 | 20231030041508.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\23885 | ||
| 090 | _a657383 | ||
| 100 | _a20180129a2017 k y0engy50 ba | ||
| 101 | 0 | _aeng | |
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aRecent Advances of Individual BODIPY and BODIPY-Based Functional Materials in Medical Diagnostics and Treatment _fYu. S. Marfin [et al.] |
|
| 203 |
_aText _celectronic |
||
| 300 | _aTitle screen | ||
| 330 | _aBackground: The group of fluorophores on boron dipyrrin platform (4,4- difluoro-4-bora3a,4a-diaza-s-indacene, also known as BODIPY) has attracted much attention in the field of molecular sensorics, including sensing of biomolecules and bioprocesses. Structural diversity of existing BODIPY with ample opportunities of directed modification of compounds makes this class of fluorophores attractive for medical and biological purposes. The recent progress in the design and functionalization of BODIPY allows using them for modification of drug micro- and nanocarriers in order to improve their therapeutic effect in cancer treatment. At the same time, integration of BODIPY into drug carriers provides the possibility of in vitro and in vivo real time imaging of used drug carriers. The high fluorescent intensity and low toxicity of BODIPY granted for conjugation with different biomolecules.Results: The present review focuses on the recent advances for application of individual BODIPY in medical diagnostics, antimicrobial activity, as well as establishing the role of BODIPY in labeling of biomolecules (e.g. proteins, hormones and DNA). Also the review highlights the potential of BODIPY in functionalization of drug micro- and nanocarriers in order to achieve better therapeutic efficiency compared with non-modified materials. The advantages derived from the use of BODIPY for preparation and modification of drug carriers are critically evaluated and potential for future challenges, especially concerning the design of innovative multi-functional BODIPY-based nanocarriers, is discussed in detail using representative examples from literature.Conclusion: Our objective was to show that BODIPY are powerful tools for bioimaging, labeling of biomolecules and construction of new multifunctional drug carriers. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 | _tCurrent Medicinal Chemistry | ||
| 463 |
_tVol. 24, iss. 25 _v[P. 2745-2772] _d2017 |
||
| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aздравоохранение | |
| 610 | 1 | _aантимикробная активность | |
| 610 | 1 | _aДНК | |
| 610 | 1 | _aРНК | |
| 610 | 1 | _aмедицинская диагностика | |
| 610 | 1 | _aлекарственные препараты | |
| 701 | 1 |
_aMarfin _bYu. S. _gYuriy |
|
| 701 | 1 |
_aSolomonov _bA. V. _gAlexey |
|
| 701 | 1 |
_aTimin _bA. S. _cChemist _cAssociate Scientist of Tomsk Polytechnic University _f1989- _gAleksandr Sergeevich _2stltpush _3(RuTPU)RU\TPU\pers\37036 |
|
| 701 | 1 |
_aRumyantsev _bE. V. _gEvgeniy |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bИсследовательская школа химических и биомедицинских технологий (ИШХБМТ) _h8120 _2stltpush _3(RuTPU)RU\TPU\col\23537 |
| 801 | 2 |
_aRU _b63413507 _c20180220 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.2174/0929867324666170601092327 | |
| 942 | _cCF | ||