| 000 | 03526nlm1a2200457 4500 | ||
|---|---|---|---|
| 001 | 657482 | ||
| 005 | 20231030041513.0 | ||
| 035 | _a(RuTPU)RU\TPU\network\24012 | ||
| 035 | _aRU\TPU\network\24001 | ||
| 090 | _a657482 | ||
| 100 | _a20180208a2017 k y0engy50 ba | ||
| 101 | 1 |
_aeng _deng |
|
| 135 | _adrcn ---uucaa | ||
| 181 | 0 | _ai | |
| 182 | 0 | _ab | |
| 200 | 1 |
_aEffects of pentoxifylline on hemodynamic, hemorheological, and microcirculatory parameters in young SHRs during arterial hypertension development _fM. B. Plotnikov [et al.] |
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| 203 |
_aText _celectronic |
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| 300 | _aTitle screen | ||
| 320 | _a[References: 62 tit.] | ||
| 330 | _aThe most common form of hypertension in young adults is isolated diastolic hypertension. Diastolic arterial pressure is determined by the total peripheral resistance and depends on both vascular hindrance and blood viscosity. The aim of our work was to study the efficiency of pentoxifylline (PTX) in young spontaneously hypertensive rats (SHRs) during the development of arterial hypertension. The effects of a treatment course with PTX (100 mg/kg/day p.o. for 6 weeks, from 5 to 11 weeks old) on the mean, systolic, and diastolic blood pressure (BP); stroke volume; cardiac output; total peripheral resistance (TPR); whole blood viscosity (BV); plasma viscosity; hematocrit; RBC aggregation and deformability; local cerebral blood flow (lCBF); and microvascularization of the visual cortex were studied in SHRs in comparison with control SHRs and Wistar Kyoto rats. PTX-treated SHRs had significantly lower systolic, diastolic, and mean BP (by 24%, 26%, and 15%, respectively) and BV (by 5-9%) and a higher erythrocyte deformability index (by 1.5-2%), lCBF (by 42%), average diameter of capillaries (by 11%), density of the capillary network (by 23%), and percentage of capillaries with a diameter of 3-7 µm in comparison with control SHRs. In conclusion, PTX exerted positive effects on the hemodynamic, hemorheological, and microcirculatory parameters in SHRs during the development of arterial hypertension. | ||
| 333 | _aРежим доступа: по договору с организацией-держателем ресурса | ||
| 461 |
_tClinical and Experimental Hypertension _d1978- |
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| 463 |
_tVol. 39, iss. 6 _v[P. 570-578] _d2017 |
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| 610 | 1 | _aэлектронный ресурс | |
| 610 | 1 | _aтруды учёных ТПУ | |
| 610 | 1 | _aпентоксифиллин | |
| 610 | 1 | _aгемодинамические процессы | |
| 610 | 1 | _aартериальная гипертония | |
| 610 | 1 | _aартериальная гипертензия | |
| 701 | 1 |
_aPlotnikov _bM. B. _gMark Borisovich |
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| 701 | 1 |
_aAliev _bI. _gOleg |
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| 701 | 1 |
_aShamanaev _bA. Yu. |
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| 701 | 1 |
_aSidekhmenova _bA. V. |
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| 701 | 1 |
_aAnfinogenova _bYa. J. _cLinguist _cLecturer of Tomsk Polytechnic University, Doctor of medical sciences _f1970- _gYana Jonovna _2stltpush _3(RuTPU)RU\TPU\pers\33592 |
|
| 701 | 1 |
_aAnishchenko _bA. M. |
|
| 701 | 1 |
_aFomina _bT. I. _gTatjyana Ivanovna |
|
| 701 | 1 |
_aArkhipov _bM. _gAlexander |
|
| 712 | 0 | 2 |
_aНациональный исследовательский Томский политехнический университет (ТПУ) _bИсследовательская школа химических и биомедицинских технологий (ИШХБМТ) _h8120 _2stltpush _3(RuTPU)RU\TPU\col\23537 |
| 801 | 2 |
_aRU _b63413507 _c20180220 _gRCR |
|
| 856 | 4 | _uhttps://doi.org/10.1080/10641963.2017.1291662 | |
| 942 | _cCF | ||